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MREO

Mereo BioPharma
MREO

84 hedge funds and large institutions have $205M invested in Mereo BioPharma in 2025 Q3 according to their latest regulatory filings, with 14 funds opening new positions, 23 increasing their positions, 23 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

1,309% more call options, than puts

Call options by funds: $5.78M | Put options by funds: $410K

0.94% more ownership

Funds ownership: 62.11% → 63.04% (+0.94%)

0% more repeat investments, than reductions

Existing positions increased: 23 | Existing positions reduced: 23

2% less funds holding

Funds holding: 86 → 84 (-2)

13% less first-time investments, than exits

New positions opened: 14 | Existing positions closed: 16

23% less capital invested

Capital invested by funds: $268M → $205M (-$62.6M)

100% less funds holding in top 10

Funds holding in top 10: 1 → 0 (-1)

Holders
84
Holders Change
-2
Holders Change %
-2.33%
% of All Funds
1.1%
Holding in Top 10
–
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-100%
% of All Funds
–
New
14
Increased
23
Reduced
23
Closed
16
Calls
$5.78M
Puts
$410K
Net Calls
+$5.37M
Net Calls Change
+$423K

Top Buyers

Rank Fund Capital Flow
1
Morgan Stanley
Morgan Stanley
New York
+$4.72M
2
Aberdeen Group
Aberdeen Group
United Kingdom
+$4.63M
3
Citadel Advisors
Citadel Advisors
Florida
+$4.44M
4
UBS AM
UBS AM
Illinois
+$3.52M
5
BOCH
Blue Owl Capital Holdings
New York
+$2.3M

Top Sellers

Rank Fund Capital Flow
1
DM
Deerfield Management
New York
-$18.2M
2
Janus Henderson Group
Janus Henderson Group
United Kingdom
-$2.58M
3
Alkeon Capital Management
Alkeon Capital Management
New York
-$1.84M
4
Renaissance Technologies
Renaissance Technologies
New York
-$1.64M
5
MP
Mangrove Partners
Connecticut
-$1.56M
Name Holding Trade Value Shares
Change 		Change in
Stake
SIA
76
Sit Investment Associates
Minnesota
$2K – – –
EWA
77
EverSource Wealth Advisors
Alabama
$859 -$98 -53 -11%
MCM
78
MAI Capital Management
Ohio
$637 – – –
NECFA
79
New England Capital Financial Advisors
Connecticut
$618 – – –
Wells Fargo
80
Wells Fargo
California
$473 – – –
PS
81
Principal Securities
Iowa
$155 – – –
US Bancorp
82
US Bancorp
Minnesota
$27 – – –
BNP Paribas Financial Markets
83
BNP Paribas Financial Markets
France
$6 – – –
DM
84
Deerfield Management
New York
– -$18.2M -6,710,429 Closed
PP
85
Paloma Partners
Connecticut
– -$804K -296,659 Closed
DIG
86
Dauntless Investment Group
New Hampshire
– -$363K -134,122 Closed
NIM
87
NEOS Investment Management
Connecticut
– -$278K -102,583 Closed
TE
88
Tema ETFs
New York
– -$278K -102,583 Closed
LSA
89
Leonteq Securities AG
Switzerland
– -$271K -100,000 Closed
Point72 Asset Management
90
Point72 Asset Management
Connecticut
– -$160K -59,200 Closed
JGC
91
J. Goldman & Co
New York
– -$142K -52,384 Closed
QC
92
Quadrature Capital
United Kingdom
– -$69.1K -25,399 Closed
GCM
93
Graham Capital Management
Connecticut
– -$57.4K -21,176 Closed
CSS
94
Cubist Systematic Strategies
Connecticut
– -$57.2K -21,099 Closed
MG
95
Marex Group
– -$27.1K -10,000 Closed
Raymond James Financial
96
Raymond James Financial
Florida
– -$4.25K -1,570 Closed
BIG
97
Brooklyn Investment Group
New York
– -$2.3K -849 Closed
S
98
SignatureFD
Georgia
– -$507 -187 Closed
T
99
Transce3nd
Texas
– -$344 -127 Closed
Royal Bank of Canada
100
Royal Bank of Canada
Ontario, Canada
– +$9 +5 New
1 2 3
4

MREO Hedge Fund Activity: Q3 2025 in Review

84 of the 7,620 institutional investors tracked by Wall St. Rank reported a position in Mereo BioPharma (MREO) for Q3 2025, worth a combined $205M — down 23% from $268M a quarter earlier.

Sellers outnumbered buyers: 16 funds closed out of MREO and 14 opened new positions — a net loss of 2 holders — while 23 trimmed existing stakes and 23 added.

The largest buyer was Morgan Stanley, adding an estimated $4.72M. The largest seller was Deerfield Management, exiting entirely with an estimated $18.2M sold.

  • 84 institutional investors held Mereo BioPharma (MREO) as of Q3 2025, down from 86 in Q2 2025.
  • Funds reported $205M of Mereo BioPharma stock for Q3 2025, down 23% quarter-over-quarter.
  • 14 funds opened new Mereo BioPharma positions in Q3 2025 and 16 closed out, a net change of -2 holders.
  • The largest Mereo BioPharma buyer in Q3 2025 was Morgan Stanley, an estimated $4.72M added.
  • The largest Mereo BioPharma seller in Q3 2025 was Deerfield Management, an estimated $18.2M sold.

Based on aggregated 13F filings for Q3 2025.