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MoonLake Immunotherapeutics

MLTX

Market cap $1.59B

130 hedge funds and large institutions have $743M invested in MoonLake Immunotherapeutics in 2025 Q4 according to their latest regulatory filings, with 47 funds opening new positions, 55 increasing their positions, 23 reducing their positions, and 47 closing their positions.

New

Increased

Maintained

Reduced

Closed

200% more funds holding in top 10

Funds holding in top 10: 1 → 3 (+2)

176% more call options, than puts

Call options by funds: $37.5M | Put options by funds: $13.6M

175% more capital invested

Capital invested by funds: $270M → $743M (+$473M)

139% more repeat investments, than reductions

Existing positions increased: 55 | Existing positions reduced: 23

29.2% more ownership

Funds ownership: 59.27% → 88.47% (+29%)

0% more first-time investments, than exits

New positions opened: 47 | Existing positions closed: 47

3% less funds holding

Funds holding: 134 → 130 (-4)

Holders

130

Holders Change

-4

Holders Change %

-2.99%

% of All Funds

1.58%

Holding in Top 10

Holding in Top 10 Change

Holding in Top 10 Change %

+200%

% of All Funds

0.04%

New

Increased

Reduced

Closed

Calls

$37.5M

Puts

$13.6M

Net Calls

+$23.9M

Net Calls Change

+$5.17M

Top Buyers

1	DTC Deep Track Capital Greenwich, Connecticut	+$54.4M
2	D.E. Shaw & Co New York	+$29.3M
3	CAM Cormorant Asset Management Boston, Massachusetts	+$27.9M
4	Janus Henderson Group London, United Kingdom	+$24.6M
5	LGM Logos Global Management San Francisco, California	+$20.6M

Top Sellers

1	ACA Avoro Capital Advisors New York	-$14.3M
2	Adage Capital Partners Boston, Massachusetts	-$10.8M
3	SSA Schonfeld Strategic Advisors New York	-$7.59M
4	Fidelity Investments Boston, Massachusetts	-$6.73M
5	IC Ikarian Capital Dallas, Texas	-$3.12M

#	Name	Holding	Trade Value	Shares Change	Change in Stake
26	WAM 26 Weiss Asset Management Boston, Massachusetts	$4.39M	+$3.93M	+332,961	New
27	SSA 27 Schonfeld Strategic Advisors New York	$4.25M	-$7.59M	-643,144	-67%
28	28 BlackRock New York	$3.78M	+$1.9M	+161,212	+129%
29	BCM 29 Boxer Capital Management San Diego, California	$3.62M	+$295K	+25,000	+10%
30	30 Goldman Sachs New York	$3.57M	-$1.09M	-92,206	-25%
31	31 Vanguard Group Malvern, Pennsylvania	$3.51M	+$1.72M	+145,907	+121%
32	FTM 32 First Turn Management Del Mar, California	$3.46M	–	–	–
33	SPS 33 Susquehanna Portfolio Strategies Bala Cynwyd, Pennsylvania	$3.35M	+$3M	+253,974	New
34	34 UBS Group Zurich, Switzerland	$3.15M	+$1.82M	+154,673	+183%
35	AG 35 Algert Global San Francisco, California	$2.92M	+$2.61M	+221,616	New
36	ECM 36 ExodusPoint Capital Management New York	$2.81M	+$2.51M	+212,996	New
37	GIM 37 Granahan Investment Management Waltham, Massachusetts	$2.61M	+$2.34M	+198,307	New
38	EHI 38 Eagle Health Investments Greenwich, Connecticut	$2.47M	+$2.21M	+187,600	New
39	TI 39 Trexquant Investment Stamford, Connecticut	$2.43M	+$2.17M	+184,319	New
40	40 Dimensional Fund Advisors Austin, Texas	$2.42M	+$2.04M	+172,550	+1,568%
41	KCM 41 Kalehua Capital Management Dallas, Texas	$2.32M	+$2.07M	+175,734	New
42	42 Fidelity Investments Boston, Massachusetts	$2.06M	-$6.73M	-570,656	-79%
43	43 Renaissance Technologies New York	$1.77M	+$1.59M	+134,472	New
44	CS 44 Candriam SCA Strassen, Luxembourg, Luxembourg	$1.77M	+$8.11K	+687	+0.5%
45	45 Two Sigma Advisers New York	$1.74M	+$1.09M	+92,376	+235%
46	46 Ameriprise Minneapolis, Minnesota	$1.73M	+$1.52M	+129,122	+7,010%
47	RHJA 47 Rice Hall James & Associates San Diego, California	$1.68M	-$87K	-7,370	-5%
48	48 TD Asset Management Toronto, Ontario, Canada	$1.67M	+$238K	+20,134	+19%
49	49 Squarepoint New York	$1.6M	+$1.07M	+90,950	+296%
50	50 Tudor Investment Corp Stamford, Connecticut	$1.36M	+$1.22M	+103,516	New