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Madrigal Pharmaceuticals
MDGL

Overview Fund Activity

318 hedge funds and large institutions have $7.82B invested in Madrigal Pharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 73 funds opening new positions, 108 increasing their positions, 91 reducing their positions, and 32 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
318
Holders Change
+36
Holders Change %
+12.77%
% of All Funds
4.32%
Holding in Top 10
12
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+20%
% of All Funds
0.16%
New
73
Increased
108
Reduced
91
Closed
32
Calls
$346M
Puts
$164M
Net Calls
+$182M
Net Calls Change
+$149M

Top Buyers

1
Holocene Advisors
Holocene Advisors
New York
$129M
2
Adage Capital Partners
Adage Capital Partners
Massachusetts
$63.5M
3
Morgan Stanley
Morgan Stanley
New York
$127M
4
Susquehanna International Group
Susquehanna International Group
Pennsylvania
$47.2M
5
HRCM
Hood River Capital Management
Florida
$80.8M

Top Sellers

1
Fidelity Investments
Fidelity Investments
Massachusetts
$216M
2
SL
Siren LLC
Connecticut
$0
3
RSCM
Rock Springs Capital Management
Maryland
$55.2M
4
Group One Trading
Group One Trading
Illinois
$0
5
VPC
Vestal Point Capital
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
Charles Schwab
26
Charles Schwab
California
$50.1M +$167K +505 +0.3%
Northern Trust
27
Northern Trust
Illinois
$50M -$1.66M -4,997 -3%
PCH
28
Polar Capital Holdings
United Kingdom
$49.8M +$4.14M +12,500 +9%
Susquehanna International Group
29
Susquehanna International Group
Pennsylvania
$47.2M +$41.8M +126,320 +774%
Artisan Partners
30
Artisan Partners
Wisconsin
$45.6M -$23.1M -69,731 -34%
AC
31
Armistice Capital
New York
$45M +$11.9M +35,883 +36%
Invesco
32
Invesco
Georgia
$44M +$1.28M +3,860 +3%
Fiera Capital (Canada)
33
Fiera Capital (Canada)
Quebec, Canada
$43.8M +$8.2M +24,757 +23%
Lord, Abbett & Co
34
Lord, Abbett & Co
New Jersey
$39.1M +$22.9M +69,107 +141%
TCM
35
Tao Capital Management
California
$37.4M -$5.88M -17,744 -14%
Connor, Clark & Lunn Investment Management (CC&L)
36
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$33.9M -$307K -928 -0.9%
MB
37
MPM BioImpact
Massachusetts
$33.3M +$33.3M +100,415 New
D.E. Shaw & Co
38
D.E. Shaw & Co
New York
$32.8M +$24.9M +75,162 +315%
Renaissance Technologies
39
Renaissance Technologies
New York
$28.2M -$25.1M -75,696 -47%
AAA
40
Affinity Asset Advisors
New York
$26.5M -$828K -2,500 -3%
EC
41
EcoR1 Capital
California
$24.8M – – –
Mirae Asset Global Investments
42
Mirae Asset Global Investments
South Korea
$23.3M +$53.6K +162 +0.2%
Victory Capital Management
43
Victory Capital Management
Texas
$22.7M -$744K -2,245 -3%
SCM
44
Soleus Capital Management
Connecticut
$22.4M +$18.7M +56,600 +519%
Point72 Asset Management
45
Point72 Asset Management
Connecticut
$21.8M +$21.8M +65,860 New
Bank of New York Mellon
46
Bank of New York Mellon
New York
$20.1M +$192K +579 +1%
Federated Hermes
47
Federated Hermes
Pennsylvania
$19.2M +$19.2M +58,025 New
Raymond James Financial
48
Raymond James Financial
Florida
$17.9M +$23.2K +70 +0.1%
Jane Street
49
Jane Street
New York
$17.2M +$14.6M +44,071 +564%
NL
50
Nuveen LLC
North Carolina
$16.5M +$16.5M +49,922 New
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