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Lyra Therapeutics
LYRA

Overview Fund Activity

57 hedge funds and large institutions have $3.23M invested in Lyra Therapeutics in 2025 Q1 according to their latest regulatory filings, with 6 funds opening new positions, 14 increasing their positions, 19 reducing their positions, and 3 closing their positions.

Holders
57
Holders Change
+3
Holders Change %
+5.56%
% of All Funds
0.77%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
6
Increased
14
Reduced
19
Closed
3
Calls
$7K
Puts
$4K
Net Calls
+$3K
Net Calls Change
-$1K

Top Buyers

1
Geode Capital Management
1
Geode Capital Management
Massachusetts
$128K
2
Susquehanna International Group
2
Susquehanna International Group
Pennsylvania
$27.5K
3
Northern Trust
3
Northern Trust
Illinois
$42K
4
RhumbLine Advisers
4
RhumbLine Advisers
Massachusetts
$11K
5
Jane Street
5
Jane Street
New York
$5.56K

Top Sellers

1
SB
1
Samsara BioCapital
California
$176K
2
Qube Research & Technologies (QRT)
2
Qube Research & Technologies (QRT)
United Kingdom
$0
3
Goldman Sachs
3
Goldman Sachs
New York
$46.8K
4
Morgan Stanley
4
Morgan Stanley
New York
$8.29K
5
JPMorgan Chase & Co
5
JPMorgan Chase & Co
New York
$7.11K
Name Market Value Shares Shares
Change 		Shares
Change %
PA
1
Perceptive Advisors
New York
$1.61M 12,757,562 – –
BlackRock
2
BlackRock
New York
$381K 3,018,986 -90,812 -3%
Vanguard Group
3
Vanguard Group
Pennsylvania
$222K 1,765,585 -21,837 -1%
SB
4
Samsara BioCapital
California
$176K 1,390,130 -575,559 -29%
IC
5
Ikarian Capital
Texas
$134K 1,058,148 – –
Geode Capital Management
6
Geode Capital Management
Massachusetts
$128K 1,016,004 +130,038 +15%
ACM
7
ADAR1 Capital Management
Texas
$67.3K 533,200 – –
State Street
8
State Street
Massachusetts
$61.7K 488,720 – –
UBS Group
9
UBS Group
Switzerland
$54.7K 434,226 +9,261 +2%
Goldman Sachs
10
Goldman Sachs
New York
$46.8K 370,194 -185,314 -33%
Two Sigma Advisers
11
Two Sigma Advisers
New York
$46K 364,478 -21,022 -5%
Northern Trust
12
Northern Trust
Illinois
$42K 332,639 +46,329 +16%
BNP Paribas Financial Markets
13
BNP Paribas Financial Markets
France
$30.6K 242,546 -2,374 -1%
BFM
14
Boothbay Fund Management
New York
$29.6K 233,989 – –
Susquehanna International Group
15
Susquehanna International Group
Pennsylvania
$27.5K 217,567 +114,137 +110%
Two Sigma Investments
16
Two Sigma Investments
New York
$24.4K 193,145 -16,852 -8%
New York State Common Retirement Fund
17
New York State Common Retirement Fund
New York
$20K 154,800 – –
Charles Schwab
18
Charles Schwab
California
$14.1K 111,609 – –
RhumbLine Advisers
19
RhumbLine Advisers
Massachusetts
$11K 87,710 +46,452 +113%
Bank of New York Mellon
20
Bank of New York Mellon
New York
$9.04K 71,585 -4,381 -6%
Morgan Stanley
21
Morgan Stanley
New York
$8.29K 65,619 -150,866 -70%
Fidelity Investments
22
Fidelity Investments
Massachusetts
$7.35K 58,213 -41,578 -42%
AQR Capital Management
23
AQR Capital Management
Connecticut
$7.33K 58,041 +29,328 +102%
JPMorgan Chase & Co
24
JPMorgan Chase & Co
New York
$7.11K 56,277 -100,165 -64%
TRCT
25
Tower Research Capital (TRC)
New York
$6.66K 52,736 +12,951 +33%
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