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Lyra Therapeutics
LYRA

Overview Fund Activity

30 hedge funds and large institutions have $4.42M invested in Lyra Therapeutics in 2025 Q2 according to their latest regulatory filings, with 8 funds opening new positions, 8 increasing their positions, 10 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
30
Holders Change
-27
Holders Change %
-47.37%
% of All Funds
0.4%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
8
Increased
8
Reduced
10
Closed
35
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
SM
Sabby Management
Florida
+$1.13M
2
Bank of America
Bank of America
North Carolina
+$252K
3
State of Wisconsin Investment Board
State of Wisconsin Investment Board
Wisconsin
+$94.1K
4
Russell Investments Group
Russell Investments Group
United Kingdom
+$14.3K
5
Royal Bank of Canada
Royal Bank of Canada
Ontario, Canada
+$8.55K

Top Sellers

1
BlackRock
BlackRock
New York
-$526K
2
SB
Samsara BioCapital
California
-$176K
3
Geode Capital Management
Geode Capital Management
Massachusetts
-$83.6K
4
UBS Group
UBS Group
Switzerland
-$78.1K
5
ACM
ADAR1 Capital Management
Texas
-$67.3K
Name Holding Trade Value Shares
Change 		Shares
Change %
Nisa Investment Advisors
26
Nisa Investment Advisors
Missouri
$90 – – –
IA
27
IFP Advisors
Florida
$80 +$80 +306 New
Raymond James Financial
28
Raymond James Financial
Florida
$72 +$72 +8 New
UBS Group
29
UBS Group
Switzerland
$18 -$78.1K -8,683 -100%
SB
30
Samsara BioCapital
California
– -$176K -27,803 Closed
ACM
31
ADAR1 Capital Management
Texas
– -$67.3K -10,664 Closed
State Street
32
State Street
Massachusetts
– -$61.7K -9,774 Closed
Goldman Sachs
33
Goldman Sachs
New York
– -$46.8K -7,404 Closed
Two Sigma Advisers
34
Two Sigma Advisers
New York
– -$46K -7,290 Closed
Northern Trust
35
Northern Trust
Illinois
– -$42K -6,653 Closed
BFM
36
Boothbay Fund Management
New York
– -$29.6K -4,680 Closed
Susquehanna International Group
37
Susquehanna International Group
Pennsylvania
– -$27.5K -4,351 Closed
Two Sigma Investments
38
Two Sigma Investments
New York
– -$24.4K -3,863 Closed
New York State Common Retirement Fund
39
New York State Common Retirement Fund
New York
– -$20K -3,096 Closed
Charles Schwab
40
Charles Schwab
California
– -$14.1K -2,232 Closed
RhumbLine Advisers
41
RhumbLine Advisers
Massachusetts
– -$11K -1,754 Closed
Bank of New York Mellon
42
Bank of New York Mellon
New York
– -$9.04K -1,432 Closed
AQR Capital Management
43
AQR Capital Management
Connecticut
– -$7.33K -1,161 Closed
Jane Street
44
Jane Street
New York
– -$5.56K -880 Closed
AllianceBernstein
45
AllianceBernstein
Tennessee
– -$4.18K -662 Closed
SEI Investments
46
SEI Investments
Pennsylvania
– -$3.83K -601 Closed
Mirae Asset Global ETFs Holdings
47
Mirae Asset Global ETFs Holdings
Hong Kong
– -$3.67K -580 Closed
CF
48
Corebridge Financial
Texas
– -$2.99K -474 Closed
Invesco
49
Invesco
Georgia
– -$2.98K -473 Closed
T. Rowe Price Associates
50
T. Rowe Price Associates
Maryland
– -$3K -351 Closed
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