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Lyra Therapeutics
LYRA

Overview Fund Activity

30 hedge funds and large institutions have $4.42M invested in Lyra Therapeutics in 2025 Q2 according to their latest regulatory filings, with 8 funds opening new positions, 2 increasing their positions, 20 reducing their positions, and 34 closing their positions.

Holders
30
Holders Change
-27
Holders Change %
-47.37%
% of All Funds
0.4%
Holding in Top 10
1
Holding in Top 10 Change
+1
Holding in Top 10 Change %
%
% of All Funds
0.01%
New
8
Increased
2
Reduced
20
Closed
34
Calls
–
Puts
–
Net Calls
–
Net Calls Change
–

Top Buyers

1
SM
1
Sabby Management
Florida
$1.13M
2
State of Wisconsin Investment Board
2
State of Wisconsin Investment Board
Wisconsin
$94.1K
3
Bank of America
3
Bank of America
North Carolina
$256K
4
Russell Investments Group
4
Russell Investments Group
United Kingdom
$14.3K
5
VNA
5
Valley National Advisers
Pennsylvania
$4K

Top Sellers

1
PA
1
Perceptive Advisors
New York
$2.29M
2
BlackRock
2
BlackRock
New York
$15.1K
3
Vanguard Group
3
Vanguard Group
Pennsylvania
$261K
4
IC
4
Ikarian Capital
Texas
$190K
5
Geode Capital Management
5
Geode Capital Management
Massachusetts
$98.5K
Name Market Value Shares Shares
Change 		Shares
Change %
Nisa Investment Advisors
26
Nisa Investment Advisors
Missouri
$90 10 -490 -98%
IA
27
IFP Advisors
Florida
$80 306 +306 New
Raymond James Financial
28
Raymond James Financial
Florida
$72 8 +8 New
UBS Group
29
UBS Group
Switzerland
$18 2 -434,224 -100%
SB
30
Samsara BioCapital
California
– – -1,390,130 Closed
ACM
31
ADAR1 Capital Management
Texas
– – -533,200 Closed
State Street
32
State Street
Massachusetts
– – -488,720 Closed
Goldman Sachs
33
Goldman Sachs
New York
– – -370,194 Closed
Two Sigma Advisers
34
Two Sigma Advisers
New York
– – -364,478 Closed
Northern Trust
35
Northern Trust
Illinois
– – -332,639 Closed
BFM
36
Boothbay Fund Management
New York
– – -233,989 Closed
Two Sigma Investments
37
Two Sigma Investments
New York
– – -193,145 Closed
New York State Common Retirement Fund
38
New York State Common Retirement Fund
New York
– – -154,800 Closed
Charles Schwab
39
Charles Schwab
California
– – -111,609 Closed
RhumbLine Advisers
40
RhumbLine Advisers
Massachusetts
– – -87,710 Closed
Bank of New York Mellon
41
Bank of New York Mellon
New York
– – -71,585 Closed
AQR Capital Management
42
AQR Capital Management
Connecticut
– – -58,041 Closed
Barclays
43
Barclays
United Kingdom
$0 48 -49,990 -100%
Jane Street
44
Jane Street
New York
– – -43,997 Closed
AllianceBernstein
45
AllianceBernstein
Tennessee
– – -33,120 Closed
SEI Investments
46
SEI Investments
Pennsylvania
– – -30,067 Closed
Mirae Asset Global ETFs Holdings
47
Mirae Asset Global ETFs Holdings
Hong Kong
– – -29,018 Closed
CF
48
Corebridge Financial
Texas
– – -23,709 Closed
Invesco
49
Invesco
Georgia
– – -23,626 Closed
T. Rowe Price Associates
50
T. Rowe Price Associates
Maryland
– – -17,541 Closed
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