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Name Holding Trade Value Shares
Change 		Change in
Stake
Primecap Management
1
Primecap Management
California
$90.4M +$1.08M +38,300 +1%
Jennison Associates
2
Jennison Associates
New York
$77.7M +$2.44M +86,738 +3%
JP Morgan Chase
3
JP Morgan Chase
New York
$61.7M +$370K +13,175 +0.5%
O
4
OrbiMed
New York
$51.5M +$6.69M +238,000 +13%
Franklin Resources
5
Franklin Resources
California
$46.4M +$15.3M +544,577 +40%
WA
6
Wasatch Advisors
Utah
$43.4M +$860K +30,588 +2%
NCGI
7
Next Century Growth Investors
Minnesota
$36.6M +$6.79M +241,495 +19%
Fidelity Investments
8
Fidelity Investments
Massachusetts
$25.2M -$2.79M -99,302 -9%
Vanguard Group
9
Vanguard Group
Pennsylvania
$20.9M +$186K +6,612 +0.8%
Invesco
10
Invesco
Georgia
$20.5M +$14.7M +521,223 +165%
BFA
11
BlackRock Fund Advisors
California
$18.6M -$788K -28,018 -4%
Lord, Abbett & Co
12
Lord, Abbett & Co
New Jersey
$18.4M +$2.55M +90,692 +14%
Schroder Investment Management Group
13
Schroder Investment Management Group
United Kingdom
$14.3M +$8.26M +293,800 +101%
RG
14
Redmile Group
California
$13.7M +$4.7M +167,082 +43%
Luther King Capital Management (LKCM)
15
Luther King Capital Management (LKCM)
Texas
$13.7M +$15.7M +559,231 New
RIM
16
RS Investment Management
California
$13.2M +$340K +12,100 +2%
ZCI
17
Zevenbergen Capital Investments
Washington
$11.2M -$3.29M -116,850 -20%
State Street
18
State Street
Massachusetts
$10.2M +$27.3K +972 +0.2%
Northern Trust
19
Northern Trust
Illinois
$8.87M +$1.17M +41,751 +13%
BIT
20
BlackRock Institutional Trust
California
$7.97M -$547K -19,454 -6%
CGI
21
CI Global Investments
California
$7.52M +$197K +7,000 +2%
SIMG
22
Stephens Investment Management Group
Texas
$6.69M +$1.23M +43,715 +19%
Millennium Management
23
Millennium Management
New York
$5.82M -$781K -27,784 -10%
RFC
24
Russell Frank Company
Washington
$5.74M +$929K +33,052 +16%
FC
25
FIC Capital
New York
$4.62M +$5.31M +188,700 New
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