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Kyverna Therapeutics

75 hedge funds and large institutions have $136M invested in Kyverna Therapeutics in 2025 Q3 according to their latest regulatory filings, with 10 funds opening new positions, 18 increasing their positions, 29 reducing their positions, and 14 closing their positions.

New
Increased
Maintained
Reduced
Closed

106,800% more call options, than puts

Call options by funds: $1.07M | Put options by funds: $1K

91% more capital invested

Capital invested by funds: $71.4M → $136M (+$64.9M)

0% more funds holding in top 10

Funds holding in top 10: 33 (0)

1.22% less ownership

Funds ownership: 53.7%52.48% (-1.2%)

5% less funds holding

Funds holding: 7975 (-4)

29% less first-time investments, than exits

New positions opened: 10 | Existing positions closed: 14

38% less repeat investments, than reductions

Existing positions increased: 18 | Existing positions reduced: 29

Holders
75
Holders Change
-4
Holders Change %
-5.06%
% of All Funds
0.98%
Holding in Top 10
3
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.04%
New
10
Increased
18
Reduced
29
Closed
14
Calls
$1.07M
Puts
$1K
Net Calls
+$1.07M
Net Calls Change
+$741K
Name Holding Trade Value Shares
Change
Change in
Stake
Manulife (Manufacturers Life Insurance)
26
Manulife (Manufacturers Life Insurance)
Ontario, Canada
$623K -$57.9K -14,489 -12%
State Street
27
State Street
Massachusetts
$548K
Two Sigma Advisers
28
Two Sigma Advisers
New York
$488K -$52K -13,000 -14%
Barclays
29
Barclays
United Kingdom
$457K +$103K +25,797 +51%
Bank of America
30
Bank of America
North Carolina
$390K +$125K +31,208 +92%
Northern Trust
31
Northern Trust
Illinois
$310K
XT
32
XTX Topco
Cayman Islands
$295K +$56.6K +14,168 +41%
Goldman Sachs
33
Goldman Sachs
New York
$259K -$373K -93,246 -68%
Stifel Financial
34
Stifel Financial
Missouri
$233K -$576 -144 -0.4%
Qube Research & Technologies (QRT)
35
Qube Research & Technologies (QRT)
United Kingdom
$220K +$90.5K +22,640 +161%
BNP Paribas Financial Markets
36
BNP Paribas Financial Markets
France
$204K +$118K +29,591 +668%
DekaBank Deutsche Girozentrale
37
DekaBank Deutsche Girozentrale
Germany
$195K
American Century Companies
38
American Century Companies
Missouri
$193K +$129K +32,205 New
Point72 Asset Management
39
Point72 Asset Management
Connecticut
$163K -$113K -28,346 -51%
CC
40
Caxton Corporation
New Jersey
$138K
CSS
41
Cubist Systematic Strategies
Connecticut
$123K -$496K -124,177 -86%
PCM
42
Prelude Capital Management
New York
$117K -$67.2K -16,809 -46%
VPIM
43
Vanguard Personalized Indexing Management
California
$113K -$915 -229 -1%
Wells Fargo
44
Wells Fargo
California
$110K +$59.8K +14,948 +449%
Citadel Advisors
45
Citadel Advisors
Florida
$106K -$1.23M -307,723 -95%
JFG
46
Jefferies Financial Group
New York
$97.8K +$65.2K +16,300 New
EI
47
Ethic Inc
New York
$92.1K -$6.73K -1,683 -10%
Federated Hermes
48
Federated Hermes
Pennsylvania
$90.9K -$115K -28,842 -66%
TI
49
Trexquant Investment
Connecticut
$90.7K +$60.4K +15,109 New
AQR Capital Management
50
AQR Capital Management
Connecticut
$81.3K -$346K -86,616 -86%

KYTX Hedge Fund Activity: Q3 2025 in Review

75 of the 7,621 institutional investors tracked by Wall St. Rank reported a position in Kyverna Therapeutics (KYTX) for Q3 2025, worth a combined $136M — up 91% from $71.4M a quarter earlier.

Sellers outnumbered buyers: 14 funds closed out of KYTX and 10 opened new positions — a net loss of 4 holders — while 29 trimmed existing stakes and 18 added.

The largest buyer was Woodline Partners, opening a new position worth an estimated $1.01M. The largest seller was T. Rowe Price Associates, cutting an estimated $1.27M.

  • 75 institutional investors held Kyverna Therapeutics (KYTX) as of Q3 2025, down from 79 in Q2 2025.
  • Funds reported $136M of Kyverna Therapeutics stock for Q3 2025, up 91% quarter-over-quarter.
  • 10 funds opened new Kyverna Therapeutics positions in Q3 2025 and 14 closed out, a net change of -4 holders.
  • The largest Kyverna Therapeutics buyer in Q3 2025 was Woodline Partners, an estimated $1.01M added.
  • The largest Kyverna Therapeutics seller in Q3 2025 was T. Rowe Price Associates, an estimated $1.27M sold.

Based on aggregated 13F filings for Q3 2025.