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IVVD

Name Holding Trade Value Shares
Change 		Change in
Stake
Janus Henderson Group
1
Janus Henderson Group
$80.9M +$14.9M +7,160,065 +28%
PA
2
Perceptive Advisors
New York
$53.8M +$45.3M +21,785,166 New
BI
3
BVF Inc
California
$48.2M +$40.6M +19,525,000 New
MC
4
Maverick Capital
Texas
$46.9M – – –
RCM
5
RA Capital Management
Massachusetts
$42.3M – – –
Point72 Asset Management
6
Point72 Asset Management
Connecticut
$41.1M -$7.59M -3,649,064 -18%
DCM
7
Driehaus Capital Management
Illinois
$32.3M +$6.15M +2,957,867 +29%
Vanguard Group
8
Vanguard Group
Pennsylvania
$26.4M +$10.3M +4,941,083 +86%
MCM
9
M28 Capital Management
Connecticut
$22.8M – – –
SVCM
10
Saturn V Capital Management
Texas
$19.1M +$16.1M +7,735,386 New
SCM
11
Soleus Capital Management
Connecticut
$19M +$16M +7,708,727 New
EAM
12
Eventide Asset Management
Massachusetts
$14.3M +$12.1M +5,809,256 New
State Street
13
State Street
Massachusetts
$13.9M +$11M +5,312,986 +1,637%
SL
14
Siren LLC
Connecticut
$9.88M +$8.32M +4,000,000 New
ACM
15
ADAR1 Capital Management
Texas
$9.63M -$7.22M -3,471,590 -47%
Balyasny Asset Management
16
Balyasny Asset Management
Illinois
$9.4M +$7.92M +3,806,976 New
Adage Capital Partners
17
Adage Capital Partners
Massachusetts
$9.04M +$7.62M +3,661,480 New
BlackRock
18
BlackRock
New York
$8.76M +$5.88M +2,828,059 +393%
6CM
19
683 Capital Management
New York
$7.16M -$7.07M -3,400,000 -54%
RG
20
Redmile Group
California
$6.62M +$823K +395,839 +17%
IC
21
Ikarian Capital
Texas
$6.56M +$1.2M +577,864 +28%
Two Sigma Investments
22
Two Sigma Investments
New York
$5.41M +$3.86M +1,856,900 +554%
Goldman Sachs
23
Goldman Sachs
New York
$5.37M +$4.43M +2,130,825 +4,964%
EP
24
Eversept Partners
New York
$5.29M +$193K +92,865 +5%
Geode Capital Management
25
Geode Capital Management
Massachusetts
$5.08M +$2.75M +1,324,128 +181%
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