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IVVD

Name Holding Trade Value Shares
Change 		Change in
Stake
Fidelity Investments
1
Fidelity Investments
Massachusetts
$663M +$619M +16,687,749 New
AI
2
Alphabet Inc
California
$240M +$211M +5,680,785 New
O
3
OrbiMed
New York
$227M +$200M +5,383,500 New
RCM
4
RA Capital Management
Massachusetts
$226M +$198M +5,340,130 New
RG
5
Redmile Group
California
$137M +$121M +3,246,960 New
ACH
6
ArrowMark Colorado Holdings
Colorado
$117M +$103M +2,772,927 New
Federated Hermes
7
Federated Hermes
Pennsylvania
$108M +$94.7M +2,552,955 New
BCLSI
8
Bain Capital Life Sciences Investors
Massachusetts
$105M +$92.3M +2,487,207 New
Vanguard Group
9
Vanguard Group
Pennsylvania
$80.7M +$70.9M +1,911,625 New
BlackRock
10
BlackRock
New York
$56.1M +$49.3M +1,329,055 New
FCMV
11
Foresite Capital Management V
California
$54.1M +$47.5M +1,280,640 New
OFM
12
Omega Fund Management
Massachusetts
$26.7M +$23.5M +632,855 New
Franklin Resources
13
Franklin Resources
California
$21.1M +$18.6M +500,014 New
Geode Capital Management
14
Geode Capital Management
Massachusetts
$15.7M +$13.8M +372,031 New
State Street
15
State Street
Massachusetts
$13.4M +$11.7M +316,078 New
AA
16
Antipodean Advisors
New York
$8.03M +$7.05M +190,000 New
Northern Trust
17
Northern Trust
Illinois
$7.86M +$6.91M +186,091 New
WP
18
Woodline Partners
California
$6.82M +$5.99M +161,459 New
Charles Schwab
19
Charles Schwab
California
$5.66M +$4.98M +134,058 New
Ensign Peak Advisors
20
Ensign Peak Advisors
Utah
$4.78M +$4.2M +113,183 New
GGHC
21
Gilder Gagnon Howe & Co
New York
$4.22M +$3.71M +99,887 New
DGM
22
Darwin Global Management
Jersey
$3.65M +$3.21M +86,528 New
Bank of New York Mellon
23
Bank of New York Mellon
New York
$3.6M +$3.16M +85,138 New
Nuveen
24
Nuveen
North Carolina
$3.1M +$2.72M +73,297 New
PPA
25
Parametric Portfolio Associates
Washington
$2.02M +$1.77M +47,823 New
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