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iShares Biotechnology ETF
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Overview Fund Activity

781 hedge funds and large institutions have $3.93B invested in iShares Biotechnology ETF in 2025 Q2 according to their latest regulatory filings, with 57 funds opening new positions, 136 increasing their positions, 341 reducing their positions, and 82 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
781
Holders Change
-40
Holders Change %
-4.87%
% of All Funds
10.48%
Holding in Top 10
7
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-12.5%
% of All Funds
0.09%
New
57
Increased
136
Reduced
341
Closed
82
Calls
$216M
Puts
$168M
Net Calls
+$47.6M
Net Calls Change
+$385M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$314M
2
Citigroup
2
Citigroup
New York
$515M
3
Morgan Stanley
3
Morgan Stanley
New York
$458M
4
JPMorgan Chase & Co
4
JPMorgan Chase & Co
New York
$105M
5
ERSOT
5
Employees Retirement System of Texas
Texas
$25M

Top Sellers

1
Bank of America
1
Bank of America
North Carolina
$776M
2
MMEA
2
Main Management ETF Advisors
California
$0
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$58.6M
4
Barclays
4
Barclays
United Kingdom
$49.4M
5
Two Sigma Investments
5
Two Sigma Investments
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
Bank of America
1
Bank of America
North Carolina
$776M -$105M -830,457 -12%
Citigroup
2
Citigroup
New York
$515M +$110M +865,823 +27%
Morgan Stanley
3
Morgan Stanley
New York
$458M +$103M +817,621 +29%
Goldman Sachs
4
Goldman Sachs
New York
$314M +$247M +1,952,538 +369%
UBS Group
5
UBS Group
Switzerland
$186M +$6.61M +52,237 +4%
JPMorgan Chase & Co
6
JPMorgan Chase & Co
New York
$105M +$44.9M +355,000 +74%
Wells Fargo
7
Wells Fargo
California
$85.8M -$26M -205,622 -23%
Royal Bank of Canada
8
Royal Bank of Canada
Ontario, Canada
$79.8M -$16.9M -133,816 -18%
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
9
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
$75.9M -$25.3M -200,000 -25%
CB
10
Commerce Bank
Missouri
$70.7M -$5.12M -40,460 -7%
BNP Paribas Financial Markets
11
BNP Paribas Financial Markets
France
$58.6M -$57.2M -452,032 -49%
Barclays
12
Barclays
United Kingdom
$49.4M -$41.8M -330,506 -46%
LPL Financial
13
LPL Financial
California
$47.7M -$3.43M -27,130 -7%
BCM
14
Bronte Capital Management
Australia
$42.1M +$4.7M +32,947 +13%
PNC Financial Services Group
15
PNC Financial Services Group
Pennsylvania
$39.6M -$2.77M -21,876 -7%
Raymond James Financial
16
Raymond James Financial
Florida
$32.9M -$11.6M -91,459 -26%
ERSOT
17
Employees Retirement System of Texas
Texas
$25M +$25M +198,000 New
Commonwealth Equity Services
18
Commonwealth Equity Services
Massachusetts
$22.9M -$1.76M -13,897 -7%
Citadel Advisors
19
Citadel Advisors
Florida
$20M +$17.9M +141,667 +847%
Rockefeller Capital Management
20
Rockefeller Capital Management
New York
$16.6M -$1.49M -11,796 -8%
AFG
21
Albion Financial Group
Utah
$15.7M +$21.8K +172 +0.1%
AT
22
Avalon Trust
New Mexico
$15.4M -$636K -5,030 -4%
GIC
23
Generali Investments CEE
Czech Republic
$14.7M +$3.81M +30,115 +35%
Stifel Financial
24
Stifel Financial
Missouri
$14.3M -$2.67M -21,064 -16%
Millennium Management
25
Millennium Management
New York
$13.7M +$8.44M +66,724 +160%
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