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iShares Biotechnology ETF
IBB

831 hedge funds and large institutions have $3.98B invested in iShares Biotechnology ETF in 2025 Q1 according to their latest regulatory filings, with 49 funds opening new positions, 194 increasing their positions, 361 reducing their positions, and 80 closing their positions.

New
Increased
Maintained
Reduced
Closed

2.23% less ownership

Funds ownership: 71% → 68.77% (-2.2%)

5% less funds holding

Funds holding: 874 → 831 (-43)

13% less capital invested

Capital invested by funds: $4.59B → $3.98B (-$611M)

27% less funds holding in top 10

Funds holding in top 10: 11 → 8 (-3)

39% less first-time investments, than exits

New positions opened: 49 | Existing positions closed: 80

46% less repeat investments, than reductions

Existing positions increased: 194 | Existing positions reduced: 361

54% less call options, than puts

Call options by funds: $293M | Put options by funds: $630M

Holders
831
Holders Change
-43
Holders Change %
-4.92%
% of All Funds
11.14%
Holding in Top 10
8
Holding in Top 10 Change
-3
Holding in Top 10 Change %
-27.27%
% of All Funds
0.11%
New
49
Increased
194
Reduced
361
Closed
80
Calls
$293M
Puts
$630M
Net Calls
-$338M
Net Calls Change
+$66.5M

Top Buyers

Rank Fund Capital Flow
1
Citigroup
Citigroup
New York
+$183M
2
UBS Group
UBS Group
Switzerland
+$42.5M
3
Wells Fargo
Wells Fargo
California
+$27.7M
4
JP Morgan Chase
JP Morgan Chase
New York
+$22.2M
5
Squarepoint
Squarepoint
New York
+$9.04M

Top Sellers

Rank Fund Capital Flow
1
Jane Street
Jane Street
New York
-$230M
2
Morgan Stanley
Morgan Stanley
New York
-$91.4M
3
Bank of America
Bank of America
North Carolina
-$70.8M
4
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
-$61M
5
Royal Bank of Canada
Royal Bank of Canada
Ontario, Canada
-$59.9M
Name Holding Trade Value Shares
Change 		Change in
Stake
WGS
826
Washington Growth Strategies
District of Columbia
$834 +$17.4K +128 New
FCMT
827
Founders Capital Management (Texas)
Texas
$780 – – –
CPBTD
828
Central Pacific Bank - Trust Division
Hawaii
$640 – – –
LC
829
Luminist Capital
Michigan
$498 – – –
WPWM
830
Western Pacific Wealth Management
Illinois
$386 – – –
Parallax Volatility Advisers
831
Parallax Volatility Advisers
California
$384 -$8.45M -62,284 -100%
MCM
832
Manchester Capital Management
Vermont
$128 – – –
SOMRS
833
State of Michigan Retirement System
Michigan
– -$18.1M -137,000 Closed
MASUI
834
MIRAE ASSET SECURITIES (USA) INC.
New York
– -$13.3M -100,248 Closed
Calamos Advisors
835
Calamos Advisors
Illinois
– -$7.44M -56,295 Closed
IAA
836
Independent Advisor Alliance
North Carolina
– -$6.77M -51,196 Closed
WSCM
837
Wellington Shields Capital Management
New York
– -$39.7K -39,663 Closed
Balyasny Asset Management
838
Balyasny Asset Management
Illinois
– -$4.86M -35,859 Closed
GC
839
Grimes & Company
Massachusetts
– -$3.46M -26,182 Closed
SW
840
SVB Wealth
Massachusetts
– -$3.09M -23,373 Closed
PPWP
841
Proquility Private Wealth Partners
Nevada
– -$2.96M -22,426 Closed
BSAM
842
Blue Square Asset Management
New York
– -$2.66M -20,150 Closed
GWA
843
Genesis Wealth Advisors
Massachusetts
– -$2.03M -15,383 Closed
Renaissance Technologies
844
Renaissance Technologies
New York
– -$1.73M -13,100 Closed
BBVA
845
Banco Bilbao Vizcaya Argentaria
Spain
– -$1.62M -12,200 Closed
PP
846
Prudential plc
United Kingdom
– -$1.42M -10,750 Closed
BGA
847
Battery Global Advisors
Massachusetts
– -$1.22M -9,233 Closed
DAM
848
Deltec Asset Management
New York
– -$992K -7,500 Closed
PEAK6
849
PEAK6
Illinois
– -$1.01M -7,437 Closed
CC
850
Centiva Capital
New York
– -$627K -4,739 Closed
32 33
34
35 36

IBB Hedge Fund Activity: Q1 2025 in Review

831 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in iShares Biotechnology ETF (IBB) for Q1 2025, worth a combined $3.98B — down 13% from $4.59B a quarter earlier.

Sellers outnumbered buyers: 80 funds closed out of IBB and 49 opened new positions — a net loss of 31 holders — while 361 trimmed existing stakes and 194 added.

The largest buyer was Citigroup, adding an estimated $183M. The largest seller was Jane Street, cutting an estimated $230M.

  • 831 institutional investors held iShares Biotechnology ETF (IBB) as of Q1 2025, down from 874 in Q4 2024.
  • Funds reported $3.98B of iShares Biotechnology ETF stock for Q1 2025, down 13% quarter-over-quarter.
  • 49 funds opened new iShares Biotechnology ETF positions in Q1 2025 and 80 closed out, a net change of -31 holders.
  • The largest iShares Biotechnology ETF buyer in Q1 2025 was Citigroup, an estimated $183M added.
  • The largest iShares Biotechnology ETF seller in Q1 2025 was Jane Street, an estimated $230M sold.

Based on aggregated 13F filings for Q1 2025.