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iShares Biotechnology ETF
IBB

803 hedge funds and large institutions have $4.63B invested in iShares Biotechnology ETF in 2025 Q3 according to their latest regulatory filings, with 85 funds opening new positions, 156 increasing their positions, 326 reducing their positions, and 65 closing their positions.

New
Increased
Maintained
Reduced
Closed

31% more first-time investments, than exits

New positions opened: 85 | Existing positions closed: 65

17% more capital invested

Capital invested by funds: $3.94B → $4.63B (+$686M)

6.06% more ownership

Funds ownership: 74.02% → 80.08% (+6.1%)

1% more funds holding

Funds holding: 797 → 803 (+6)

0% more funds holding in top 10

Funds holding in top 10: 7 → 7 (0)

27% less call options, than puts

Call options by funds: $185M | Put options by funds: $253M

52% less repeat investments, than reductions

Existing positions increased: 156 | Existing positions reduced: 326

Holders
803
Holders Change
+6
Holders Change %
+0.75%
% of All Funds
10.54%
Holding in Top 10
7
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.09%
New
85
Increased
156
Reduced
326
Closed
65
Calls
$185M
Puts
$253M
Net Calls
-$68.5M
Net Calls Change
-$116M

Top Buyers

1
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
+$198M
2
JFG
Jefferies Financial Group
New York
+$61.5M
3
Jane Street
Jane Street
New York
+$38.2M
4
JP Morgan Chase
JP Morgan Chase
New York
+$31M
5
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$20.5M

Top Sellers

1
Morgan Stanley
Morgan Stanley
New York
-$67.4M
2
UBS Group
UBS Group
Switzerland
-$51.4M
3
Citigroup
Citigroup
New York
-$48.2M
4
Bank of America
Bank of America
North Carolina
-$33.2M
5
Citadel Advisors
Citadel Advisors
Florida
-$15.1M
Name Holding Trade Value Shares
Change 		Change in
Stake
FFL
726
Financial Freedom LLC
Ohio
$14.5K – – –
Allspring Global Investments
727
Allspring Global Investments
North Carolina
$14.4K +$13.7K +100 New
AFWM
728
Abich Financial Wealth Management
Virginia
$13.7K +$13K +95 New
TAM
729
Tucker Asset Management
Colorado
$13.4K +$12.7K +93 New
IBOK
730
Independence Bank of Kentucky
Kentucky
$12.3K -$2.05K -15 -15%
SFCL
731
Strengthening Families & Communities LLC
Massachusetts
$11.9K +$11.2K +82 New
MBFW
732
Morton Brown Family Wealth
Pennsylvania
$11.4K – – –
SN
733
Sittner & Nelson
Oregon
$11.1K – – –
CIA
734
Cape Investment Advisory
Georgia
$11K -$136 -1 -1%
CB
735
Centennial Bank
Arkansas
$10.8K – – –
HCM
736
Hollencrest Capital Management
California
$10.8K – – –
RMP
737
Richards, Merrill & Peterson
Washington
$10.8K – – –
SMA
738
Sage Mountain Advisors
Georgia
$10.8K – – –
KHC
739
Koesten Hirschmann & Crabtree
Kansas
$10.4K – – –
CMP
740
Coston McIsaac & Partners
Maine
$10K – – –
CCMI
741
Creative Capital Management Investments
California
$9.82K – – –
S
742
Sachetta
Massachusetts
$9.38K – – –
BIM
743
Breakwater Investment Management
Washington
$9.1K – – –
DSC
744
Duncker Streett & Co
Missouri
$9.1K – – –
RWM
745
Rialto Wealth Management
New York
$8.66K – – –
GCM
746
Gables Capital Management
Florida
$8.66K – – –
PWA
747
Physician Wealth Advisors
Utah
$8.2K -$1.91K -14 -20%
RMC
748
Resources Management Corp
Connecticut
$8K -$27.3K -200 -78%
FIM
749
FWL Investment Management
Texas
$7.51K -$546 -4 -7%
TAM
750
Townsend Asset Management
North Carolina
$7.47K – – –
28 29
30
31 32

IBB Hedge Fund Activity: Q3 2025 in Review

803 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in iShares Biotechnology ETF (IBB) for Q3 2025, worth a combined $4.63B — up 17% from $3.94B a quarter earlier.

Buyers outnumbered sellers: 85 funds opened new IBB positions and 65 closed out — a net gain of 20 holders — while 156 added to existing stakes and 326 trimmed.

The largest buyer was BNP Paribas Financial Markets, adding an estimated $198M. The largest seller was Morgan Stanley, cutting an estimated $67.4M.

  • 803 institutional investors held iShares Biotechnology ETF (IBB) as of Q3 2025, up from 797 in Q2 2025.
  • Funds reported $4.63B of iShares Biotechnology ETF stock for Q3 2025, up 17% quarter-over-quarter.
  • 85 funds opened new iShares Biotechnology ETF positions in Q3 2025 and 65 closed out, a net change of +20 holders.
  • The largest iShares Biotechnology ETF buyer in Q3 2025 was BNP Paribas Financial Markets, an estimated $198M added.
  • The largest iShares Biotechnology ETF seller in Q3 2025 was Morgan Stanley, an estimated $67.4M sold.

Based on aggregated 13F filings for Q3 2025.