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iShares Biotechnology ETF
IBB

803 hedge funds and large institutions have $4.63B invested in iShares Biotechnology ETF in 2025 Q3 according to their latest regulatory filings, with 85 funds opening new positions, 156 increasing their positions, 326 reducing their positions, and 65 closing their positions.

New
Increased
Maintained
Reduced
Closed

31% more first-time investments, than exits

New positions opened: 85 | Existing positions closed: 65

17% more capital invested

Capital invested by funds: $3.94B → $4.63B (+$686M)

6.06% more ownership

Funds ownership: 74.02% → 80.08% (+6.1%)

1% more funds holding

Funds holding: 797 → 803 (+6)

0% more funds holding in top 10

Funds holding in top 10: 7 → 7 (0)

27% less call options, than puts

Call options by funds: $185M | Put options by funds: $253M

52% less repeat investments, than reductions

Existing positions increased: 156 | Existing positions reduced: 326

Holders
803
Holders Change
+6
Holders Change %
+0.75%
% of All Funds
10.54%
Holding in Top 10
7
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.09%
New
85
Increased
156
Reduced
326
Closed
65
Calls
$185M
Puts
$253M
Net Calls
-$68.5M
Net Calls Change
-$116M

Top Buyers

1
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
+$198M
2
JFG
Jefferies Financial Group
New York
+$61.5M
3
Jane Street
Jane Street
New York
+$38.2M
4
JP Morgan Chase
JP Morgan Chase
New York
+$31M
5
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$20.5M

Top Sellers

1
Morgan Stanley
Morgan Stanley
New York
-$67.4M
2
UBS Group
UBS Group
Switzerland
-$51.4M
3
Citigroup
Citigroup
New York
-$48.2M
4
Bank of America
Bank of America
North Carolina
-$33.2M
5
Citadel Advisors
Citadel Advisors
Florida
-$15.1M
Name Holding Trade Value Shares
Change 		Change in
Stake
GIC
26
Generali Investments CEE
Czech Republic
$16.8M – – –
Thrivent Financial for Lutherans
27
Thrivent Financial for Lutherans
Minnesota
$16.1M +$840K +6,157 +6%
Ameriprise
28
Ameriprise
Minnesota
$15.3M +$288K +2,112 +2%
Stifel Financial
29
Stifel Financial
Missouri
$14.9M -$1.36M -9,984 -9%
DCM
30
DAFNA Capital Management
California
$14.8M – – –
IHL
31
Investment House LLC
California
$14.3M +$529K +3,873 +4%
Canada Life
32
Canada Life
Manitoba, Canada
$13.6M -$698K -5,112 -5%
Osaic Holdings
33
Osaic Holdings
Arizona
$13.5M +$691K +5,061 +6%
Susquehanna International Group
34
Susquehanna International Group
Pennsylvania
$12.3M +$2.92M +21,389 +33%
CM
35
Caption Management
Oklahoma
$11.3M +$10.7M +78,500 New
FCC
36
Florin Court Capital
United Kingdom
$11.1M +$10.5M +77,000 New
MIM
37
Miller Investment Management
Pennsylvania
$11.1M -$721K -5,282 -6%
MCM
38
MAI Capital Management
Ohio
$11M +$824K +6,035 +9%
AP
39
Appleton Partners
Massachusetts
$10.7M +$2.59K +19 +0%
FMI
40
Factory Mutual Insurance
Massachusetts
$10.3M – – –
Creative Planning
41
Creative Planning
Kansas
$9.73M +$263K +1,927 +3%
Millennium Management
42
Millennium Management
New York
$9.62M -$5.7M -41,792 -39%
MML Investors Services
43
MML Investors Services
Massachusetts
$9.59M -$131K -961 -1%
Two Sigma Investments
44
Two Sigma Investments
New York
$9.49M +$8.97M +65,707 New
CA
45
Cumberland Advisors
Florida
$9.44M -$71K -520 -0.8%
EAM
46
Erste Asset Management
Austria
$9.31M +$50.5K +370 +0.6%
FNFDCM
47
Folger Nolan Fleming Douglas Capital Management
District of Columbia
$9M -$37.8K -277 -0.4%
Cetera Investment Advisers
48
Cetera Investment Advisers
Illinois
$8.76M -$110K -806 -1%
Cambridge Investment Research Advisors
49
Cambridge Investment Research Advisors
Iowa
$8.32M -$54.7K -401 -0.7%
TWM
50
Tradition Wealth Management
Minnesota
$8.29M -$89.5K -656 -1%
1
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IBB Hedge Fund Activity: Q3 2025 in Review

803 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in iShares Biotechnology ETF (IBB) for Q3 2025, worth a combined $4.63B — up 17% from $3.94B a quarter earlier.

Buyers outnumbered sellers: 85 funds opened new IBB positions and 65 closed out — a net gain of 20 holders — while 156 added to existing stakes and 326 trimmed.

The largest buyer was BNP Paribas Financial Markets, adding an estimated $198M. The largest seller was Morgan Stanley, cutting an estimated $67.4M.

  • 803 institutional investors held iShares Biotechnology ETF (IBB) as of Q3 2025, up from 797 in Q2 2025.
  • Funds reported $4.63B of iShares Biotechnology ETF stock for Q3 2025, up 17% quarter-over-quarter.
  • 85 funds opened new iShares Biotechnology ETF positions in Q3 2025 and 65 closed out, a net change of +20 holders.
  • The largest iShares Biotechnology ETF buyer in Q3 2025 was BNP Paribas Financial Markets, an estimated $198M added.
  • The largest iShares Biotechnology ETF seller in Q3 2025 was Morgan Stanley, an estimated $67.4M sold.

Based on aggregated 13F filings for Q3 2025.