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iShares Biotechnology ETF
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Overview Fund Activity

781 hedge funds and large institutions have $3.93B invested in iShares Biotechnology ETF in 2025 Q2 according to their latest regulatory filings, with 57 funds opening new positions, 136 increasing their positions, 341 reducing their positions, and 82 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
781
Holders Change
-40
Holders Change %
-4.87%
% of All Funds
10.48%
Holding in Top 10
7
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-12.5%
% of All Funds
0.09%
New
57
Increased
136
Reduced
341
Closed
82
Calls
$216M
Puts
$168M
Net Calls
+$47.6M
Net Calls Change
+$385M

Top Buyers

1
Goldman Sachs
1
Goldman Sachs
New York
$314M
2
Citigroup
2
Citigroup
New York
$515M
3
Morgan Stanley
3
Morgan Stanley
New York
$458M
4
JPMorgan Chase & Co
4
JPMorgan Chase & Co
New York
$105M
5
ERSOT
5
Employees Retirement System of Texas
Texas
$25M

Top Sellers

1
Bank of America
1
Bank of America
North Carolina
$776M
2
MMEA
2
Main Management ETF Advisors
California
$0
3
BNP Paribas Financial Markets
3
BNP Paribas Financial Markets
France
$58.6M
4
Barclays
4
Barclays
United Kingdom
$49.4M
5
Two Sigma Investments
5
Two Sigma Investments
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
Focus Partners Wealth
26
Focus Partners Wealth
Massachusetts
$13.6M -$836K -6,610 -6%
Thrivent Financial for Lutherans
27
Thrivent Financial for Lutherans
Minnesota
$13.4M +$980K +7,750 +8%
Ameriprise
28
Ameriprise
Minnesota
$13.2M -$1.77M -13,991 -12%
DCM
29
DAFNA Capital Management
California
$13M – – –
Canada Life
30
Canada Life
Manitoba, Canada
$12.8M -$218K -1,717 -2%
IHL
31
Investment House LLC
California
$12M +$1.18M +9,292 +11%
Capital Fund Management (CFM)
32
Capital Fund Management (CFM)
France
$11.7M -$6.15M -48,619 -34%
Osaic Holdings
33
Osaic Holdings
Arizona
$11.4M -$620K -4,708 -5%
MIM
34
Miller Investment Management
Pennsylvania
$10.4M -$14.5K -115 -0.1%
DWP
35
Destiny Wealth Partners
Florida
$9.59M +$749K +5,919 +8%
AP
36
Appleton Partners
Massachusetts
$9.35M -$568K -4,488 -6%
FMI
37
Factory Mutual Insurance
Massachusetts
$8.98M – – –
MCM
38
MAI Capital Management
Ohio
$8.9M -$3.52M -27,812 -28%
MML Investors Services
39
MML Investors Services
Massachusetts
$8.52M +$291K +2,302 +4%
CA
40
Cumberland Advisors
Florida
$8.34M -$952K -7,525 -10%
Creative Planning
41
Creative Planning
Kansas
$8.28M -$276K -2,180 -3%
Squarepoint
42
Squarepoint
New York
$8.28M -$829K -6,554 -9%
EAM
43
Erste Asset Management
Austria
$8.11M +$139K +1,100 +2%
Susquehanna International Group
44
Susquehanna International Group
Pennsylvania
$8.08M -$5.32M -42,060 -40%
ATPW
45
Ashton Thomas Private Wealth
Arizona
$8.06M +$7.13M +56,369 +770%
FNFDCM
46
Folger Nolan Fleming Douglas Capital Management
District of Columbia
$7.92M -$189K -1,495 -2%
GF
47
Gray Foundation
New York
$7.78M -$13.1M -103,360 -63%
Cetera Investment Advisers
48
Cetera Investment Advisers
Illinois
$7.77M -$186K -1,467 -2%
Brown Advisory
49
Brown Advisory
Maryland
$7.58M -$2.6M -20,590 -26%
PGFC
50
Peapack-Gladstone Financial Corp
New Jersey
$7.39M -$492K -3,886 -6%
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