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iShares Biotechnology ETF
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Overview Fund Activity

782 hedge funds and large institutions have $3.93B invested in iShares Biotechnology ETF in 2025 Q2 according to their latest regulatory filings, with 57 funds opening new positions, 136 increasing their positions, 342 reducing their positions, and 82 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
782
Holders Change
-39
Holders Change %
-4.75%
% of All Funds
10.49%
Holding in Top 10
7
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-12.5%
% of All Funds
0.09%
New
57
Increased
136
Reduced
342
Closed
82
Calls
$216M
Puts
$168M
Net Calls
+$47.6M
Net Calls Change
+$385M

Top Buyers

1
Goldman Sachs
Goldman Sachs
New York
$314M
2
Citigroup
Citigroup
New York
$515M
3
Morgan Stanley
Morgan Stanley
New York
$458M
4
JPMorgan Chase & Co
JPMorgan Chase & Co
New York
$105M
5
ERSOT
Employees Retirement System of Texas
Texas
$25M

Top Sellers

1
Bank of America
Bank of America
North Carolina
$776M
2
MMEA
Main Management ETF Advisors
California
$0
3
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
$58.6M
4
Barclays
Barclays
United Kingdom
$49.4M
5
Two Sigma Investments
Two Sigma Investments
New York
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
SPC
301
Sigma Planning Corp
Michigan
$635K -$149K -1,175 -19%
MA
302
MYDA Advisors
New York
$633K -$633K -5,000 -50%
SMC
303
Smith, Moore & Co
Missouri
$624K -$22.1K -175 -3%
AAS
304
Ameritas Advisory Services
Nebraska
$618K -$3.29M -25,989 -84%
MIM
305
Marco Investment Management
Georgia
$618K – – –
DADC
306
D.A. Davidson & Co
Montana
$617K +$131K +1,039 +27%
CAMG
307
CWA Asset Management Group
Florida
$612K -$109K -864 -15%
HTC
308
Haverford Trust Company
Pennsylvania
$611K – – –
FDCDDQ
309
Federation des caisses Desjardins du Quebec
Quebec, Canada
$599K -$8.98K -71 -1%
SFG
310
Sovereign Financial Group
Connecticut
$597K -$17K -134 -3%
TTWM
311
TCV Trust & Wealth Management
Virginia
$595K – – –
DWM
312
Dakota Wealth Management
Florida
$594K -$1.35M -10,644 -69%
Walleye Capital
313
Walleye Capital
New York
$589K +$125K +985 +27%
BBVA
314
Banco Bilbao Vizcaya Argentaria
Spain
$588K +$588K +4,645 New
TSS
315
Two Sigma Securities
New York
$588K +$588K +4,647 New
AG
316
Ascent Group
Virginia
$588K – – –
TCM
317
Triumph Capital Management
Colorado
$587K -$35.8K -283 -6%
RFC
318
Regions Financial Corp
Alabama
$586K -$105K -827 -15%
JWCA
319
J.W. Cole Advisors
Florida
$585K -$15.1K -119 -3%
EWM
320
Endowment Wealth Management
Wisconsin
$580K +$135K +1,070 +30%
MWM
321
Meridian Wealth Management
Kentucky
$579K +$29.5K +233 +5%
MGIA
322
Moneta Group Investment Advisors
Missouri
$569K +$75.8K +599 +15%
HI
323
Humankind Investments
New York
$569K – – –
RIL
324
Rothschild Investment LLC
Illinois
$557K -$174K -1,379 -24%
PI
325
PFG Investments
New York
$556K -$173K -1,370 -24%
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