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iShares Biotechnology ETF
IBB

803 hedge funds and large institutions have $4.63B invested in iShares Biotechnology ETF in 2025 Q3 according to their latest regulatory filings, with 85 funds opening new positions, 156 increasing their positions, 326 reducing their positions, and 65 closing their positions.

New
Increased
Maintained
Reduced
Closed

31% more first-time investments, than exits

New positions opened: 85 | Existing positions closed: 65

17% more capital invested

Capital invested by funds: $3.94B → $4.63B (+$686M)

6.06% more ownership

Funds ownership: 74.02% → 80.08% (+6.1%)

1% more funds holding

Funds holding: 797 → 803 (+6)

0% more funds holding in top 10

Funds holding in top 10: 7 → 7 (0)

27% less call options, than puts

Call options by funds: $185M | Put options by funds: $253M

52% less repeat investments, than reductions

Existing positions increased: 156 | Existing positions reduced: 326

Holders
803
Holders Change
+6
Holders Change %
+0.75%
% of All Funds
10.54%
Holding in Top 10
7
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.09%
New
85
Increased
156
Reduced
326
Closed
65
Calls
$185M
Puts
$253M
Net Calls
-$68.5M
Net Calls Change
-$116M

Top Buyers

1
BNP Paribas Financial Markets
BNP Paribas Financial Markets
France
+$198M
2
JFG
Jefferies Financial Group
New York
+$61.5M
3
Jane Street
Jane Street
New York
+$38.2M
4
JP Morgan Chase
JP Morgan Chase
New York
+$31M
5
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Healthcare of Ontario Pension Plan (HOOPP) Trust Fund
Ontario, Canada
+$20.5M

Top Sellers

1
Morgan Stanley
Morgan Stanley
New York
-$67.4M
2
UBS Group
UBS Group
Switzerland
-$51.4M
3
Citigroup
Citigroup
New York
-$48.2M
4
Bank of America
Bank of America
North Carolina
-$33.2M
5
Citadel Advisors
Citadel Advisors
Florida
-$15.1M
Name Holding Trade Value Shares
Change 		Change in
Stake
IC
226
IEQ Capital
California
$1.08M +$232K +1,703 +30%
RWPA
227
Richard W. Paul & Associates
Michigan
$1.08M +$22.9K +168 +2%
XT
228
XTX Topco
Cayman Islands
$1.07M +$271K +1,985 +37%
AWA
229
Arkadios Wealth Advisors
Georgia
$1.07M +$64.2K +470 +7%
AHC
230
Adell Harriman & Carpenter
Texas
$1.07M -$24.2K -177 -2%
IWC
231
Integrated Wealth Concepts
Massachusetts
$1.06M -$74.9K -549 -7%
SDAM
232
Shulman DeMeo Asset Management
New York
$1.06M -$4.23K -31 -0.4%
MIA
233
Milestone Investment Advisors
Wisconsin
$1.04M -$19.5K -143 -2%
FFN
234
Focus Financial Network
Minnesota
$1.04M -$19.8K -145 -2%
PG
235
Proffitt & Goodson
Tennessee
$1.01M -$8.46K -62 -0.9%
AWM
236
Avior Wealth Management
Nebraska
$1.01M +$10.4K +76 +1%
CSS
237
Cubist Systematic Strategies
Connecticut
$1M +$947K +6,941 New
SMFG
238
Sumitomo Mitsui Financial Group
Japan
$1M -$77.8K -570 -8%
MFG
239
Merit Financial Group
Georgia
$999K -$1.06M -7,795 -53%
FT
240
Fiduciary Trust
Massachusetts
$987K – – –
FWCM
241
Ferguson Wellman Capital Management
Oregon
$987K +$14.7K +108 +2%
BWFA
242
Baltimore-Washington Financial Advisors
Maryland
$977K -$4.09K -30 -0.4%
MA
243
Mutual Advisors
Nebraska
$975K -$194K -1,421 -18%
KAM
244
Knightsbridge Asset Management
California
$974K -$53.2K -390 -5%
SEIA
245
Signature Estate & Investment Advisors
California
$964K -$57.9K -424 -6%
LA
246
LM Advisors
California
$948K – – –
TRCT
247
Tower Research Capital (TRC)
New York
$947K -$6.07M -44,477 -87%
WGS
248
Washington Growth Strategies
District of Columbia
$942K – – –
TPCW
249
TD Private Client Wealth
New York
$940K -$148K -1,084 -14%
NM
250
NWI Management
New York
$938K – – –
8 9
10
11 12

IBB Hedge Fund Activity: Q3 2025 in Review

803 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in iShares Biotechnology ETF (IBB) for Q3 2025, worth a combined $4.63B — up 17% from $3.94B a quarter earlier.

Buyers outnumbered sellers: 85 funds opened new IBB positions and 65 closed out — a net gain of 20 holders — while 156 added to existing stakes and 326 trimmed.

The largest buyer was BNP Paribas Financial Markets, adding an estimated $198M. The largest seller was Morgan Stanley, cutting an estimated $67.4M.

  • 803 institutional investors held iShares Biotechnology ETF (IBB) as of Q3 2025, up from 797 in Q2 2025.
  • Funds reported $4.63B of iShares Biotechnology ETF stock for Q3 2025, up 17% quarter-over-quarter.
  • 85 funds opened new iShares Biotechnology ETF positions in Q3 2025 and 65 closed out, a net change of +20 holders.
  • The largest iShares Biotechnology ETF buyer in Q3 2025 was BNP Paribas Financial Markets, an estimated $198M added.
  • The largest iShares Biotechnology ETF seller in Q3 2025 was Morgan Stanley, an estimated $67.4M sold.

Based on aggregated 13F filings for Q3 2025.