Fortress Biotech
FBIO
52 hedge funds and large institutions have $21.2M invested in Fortress Biotech in 2025 Q4 according to their latest regulatory filings, with 13 funds opening new positions, 16 increasing their positions, 14 reducing their positions, and 15 closing their positions.
29% more capital invested
Capital invested by funds: $16.5M → $21.2M (+$4.75M)
14% more repeat investments, than reductions
Existing positions increased: 16 | Existing positions reduced: 14
3.64% more ownership
Funds ownership: 15.01% → 18.65% (+3.6%)
7% less funds holding
Funds holding: 56 → 52 (-4)
13% less first-time investments, than exits
New positions opened: 13 | Existing positions closed: 15
44% less call options, than puts
Call options by funds: $1.19M | Put options by funds: $2.12M
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
OM
Opaleye Management
Boston,
Massachusetts
|
+$3.11M |
| 2 |
BCM
Bridgeway Capital Management
Houston,
Texas
|
+$520K |
| 3 |
Vanguard Group
Malvern,
Pennsylvania
|
+$428K |
| 4 |
Two Sigma Investments
New York
|
+$154K |
| 5 |
Man Group
London,
United Kingdom
|
+$150K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Susquehanna International Group
Bala Cynwyd,
Pennsylvania
|
-$360K |
| 2 |
HF
HRT Financial
New York
|
-$170K |
| 3 |
Acadian Asset Management
Boston,
Massachusetts
|
-$158K |
| 4 |
Simplex Trading
Chicago,
Illinois
|
-$155K |
| 5 |
TSS
Two Sigma Securities
New York
|
-$113K |
FBIO Hedge Fund Activity: Q4 2025 in Review
52 of the 8,267 institutional investors tracked by Wall St. Rank reported a position in Fortress Biotech (FBIO) for Q4 2025, worth a combined $21.2M — up 29% from $16.5M a quarter earlier.
Sellers outnumbered buyers: 15 funds closed out of FBIO and 13 opened new positions — a net loss of 2 holders — while 14 trimmed existing stakes and 16 added.
The largest buyer was Opaleye Management, opening a new position worth an estimated $3.11M. The largest seller was Susquehanna International Group, cutting an estimated $360K.
- 52 institutional investors held Fortress Biotech (FBIO) as of Q4 2025, down from 56 in Q3 2025.
- Funds reported $21.2M of Fortress Biotech stock for Q4 2025, up 29% quarter-over-quarter.
- 13 funds opened new Fortress Biotech positions in Q4 2025 and 15 closed out, a net change of -2 holders.
- The largest Fortress Biotech buyer in Q4 2025 was Opaleye Management, an estimated $3.11M added.
- The largest Fortress Biotech seller in Q4 2025 was Susquehanna International Group, an estimated $360K sold.
Based on aggregated 13F filings for Q4 2025.