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Erasca
ERAS

154 hedge funds and large institutions have $816M invested in Erasca in 2025 Q4 according to their latest regulatory filings, with 32 funds opening new positions, 44 increasing their positions, 47 reducing their positions, and 18 closing their positions.

New
Increased
Maintained
Reduced
Closed

4,833% more call options, than puts

Call options by funds: $10.9M | Put options by funds: $221K

78% more first-time investments, than exits

New positions opened: 32 | Existing positions closed: 18

74% more capital invested

Capital invested by funds: $469M → $816M (+$347M)

67% more funds holding in top 10

Funds holding in top 10: 3 → 5 (+2)

9% more funds holding

Funds holding: 141 → 154 (+13)

1.53% more ownership

Funds ownership: 75.76% → 77.29% (+1.5%)

6% less repeat investments, than reductions

Existing positions increased: 44 | Existing positions reduced: 47

Holders
154
Holders Change
+13
Holders Change %
+9.22%
% of All Funds
1.87%
Holding in Top 10
5
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+66.67%
% of All Funds
0.06%
New
32
Increased
44
Reduced
47
Closed
18
Calls
$10.9M
Puts
$221K
Net Calls
+$10.7M
Net Calls Change
+$10.1M

Top Buyers

1
State Street
State Street
Massachusetts
+$6.03M
2
ECM
ExodusPoint Capital Management
New York
+$4.19M
3
RSCM
Rock Springs Capital Management
Maryland
+$2.68M
4
Goldman Sachs
Goldman Sachs
New York
+$2.29M
5
IC
Ikarian Capital
Texas
+$2.07M

Top Sellers

1
T. Rowe Price Investment Management
T. Rowe Price Investment Management
Maryland
-$11.6M
2
LGM
Logos Global Management
California
-$6.05M
3
SCM
Sio Capital Management
New York
-$2.99M
4
Millennium Management
Millennium Management
New York
-$1.9M
5
Royal Bank of Canada
Royal Bank of Canada
Ontario, Canada
-$1.87M
Name Holding Trade Value Shares
Change 		Change in
Stake
FLSM
1
Frazier Life Sciences Management
California
$84.6M – – –
VA
2
VR Adviser
New York
$66.4M – – –
T. Rowe Price Investment Management
3
T. Rowe Price Investment Management
Maryland
$59.9M -$11.6M -4,120,492 -20%
BlackRock
4
BlackRock
New York
$58M +$1.48M +526,011 +3%
SCM
5
Suvretta Capital Management
New York
$53.9M – – –
PBA
6
Paradigm Biocapital Advisors
New York
$52.7M +$1.68M +599,078 +4%
LGM
7
Logos Global Management
California
$48.4M -$6.05M -2,150,000 -14%
Vanguard Group
8
Vanguard Group
Pennsylvania
$47.7M +$911 +324 +0%
AVM
9
Arch Venture Management
Illinois
$41.1M – – –
VC
10
Vivo Capital
California
$34.5M – – –
SL
11
Siren LLC
Connecticut
$32.6M – – –
State Street
12
State Street
Massachusetts
$23M +$6.03M +2,145,386 +53%
5VM
13
5AM Venture Management
California
$20.1M – – –
Geode Capital Management
14
Geode Capital Management
Massachusetts
$18.3M +$219K +77,772 +2%
AAA
15
Affinity Asset Advisors
New York
$14.5M -$1.08M -385,787 -9%
SSC
16
Spruce Street Capital
New York
$14.5M +$10.9M +3,889,632 New
Goldman Sachs
17
Goldman Sachs
New York
$12.4M +$2.29M +814,230 +32%
ACM
18
AH Capital Management
California
$10.6M – – –
Millennium Management
19
Millennium Management
New York
$8.33M -$1.9M -676,868 -23%
SCM
20
Soleus Capital Management
Connecticut
$8.04M – – –
WP
21
Woodline Partners
California
$7.18M +$1.11M +396,252 +26%
Dimensional Fund Advisors
22
Dimensional Fund Advisors
Texas
$6.6M +$1.14M +403,750 +29%
Charles Schwab
23
Charles Schwab
California
$6.23M -$146K -51,952 -3%
Bank of America
24
Bank of America
North Carolina
$6M +$218K +77,576 +5%
ECM
25
ExodusPoint Capital Management
New York
$5.55M +$4.19M +1,490,967 New
1
2 3 4 5

ERAS Hedge Fund Activity: Q4 2025 in Review

154 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in Erasca (ERAS) for Q4 2025, worth a combined $816M — up 74% from $469M a quarter earlier.

Buyers outnumbered sellers: 32 funds opened new ERAS positions and 18 closed out — a net gain of 14 holders — while 44 added to existing stakes and 47 trimmed.

The largest buyer was State Street, adding an estimated $6.03M. The largest seller was T. Rowe Price Investment Management, cutting an estimated $11.6M.

  • 154 institutional investors held Erasca (ERAS) as of Q4 2025, up from 141 in Q3 2025.
  • Funds reported $816M of Erasca stock for Q4 2025, up 74% quarter-over-quarter.
  • 32 funds opened new Erasca positions in Q4 2025 and 18 closed out, a net change of +14 holders.
  • The largest Erasca buyer in Q4 2025 was State Street, an estimated $6.03M added.
  • The largest Erasca seller in Q4 2025 was T. Rowe Price Investment Management, an estimated $11.6M sold.

Based on aggregated 13F filings for Q4 2025.