Ensysce Biosciences
ENSC
17 hedge funds and large institutions have $461K invested in Ensysce Biosciences in 2025 Q4 according to their latest regulatory filings, with 5 funds opening new positions, 7 increasing their positions, 1 reducing their positions, and 5 closing their positions.
600% more repeat investments, than reductions
Existing positions increased: 7 | Existing positions reduced: 1
1.99% more ownership
Funds ownership: 11.85% → 13.84% (+2%)
0% more funds holding
Funds holding: 17 → 17 (0)
0% more first-time investments, than exits
New positions opened: 5 | Existing positions closed: 5
45% less capital invested
Capital invested by funds: $834K → $461K (-$373K)
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Adage Capital Partners
Boston,
Massachusetts
|
+$139K |
| 2 |
DS
DRW Securities
Chicago,
Illinois
|
+$54.4K |
| 3 |
HF
HRT Financial
New York
|
+$45.5K |
| 4 |
TSS
Two Sigma Securities
New York
|
+$40.1K |
| 5 |
WN
Williams & Novak
Westlake Village,
California
|
+$33.1K |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Renaissance Technologies
New York
|
-$36.9K |
| 2 |
Citadel Advisors
Miami,
Florida
|
-$34.4K |
| 3 |
VF
Virtu Financial
New York
|
-$34K |
| 4 |
XT
XTX Topco
George Town,
Cayman Islands
|
-$26K |
| 5 |
UBS Group
Zurich,
Switzerland
|
-$1.3K |
ENSC Hedge Fund Activity: Q4 2025 in Review
17 of the 8,280 institutional investors tracked by Wall St. Rank reported a position in Ensysce Biosciences (ENSC) for Q4 2025, worth a combined $461K — down 45% from $834K a quarter earlier.
Fund positioning in ENSC was balanced in Q4 2025: 5 funds opened new positions, 5 closed out, 7 added to existing stakes and 1 trimmed.
The largest buyer was Adage Capital Partners, adding an estimated $139K. The largest seller was Renaissance Technologies, exiting entirely with an estimated $36.9K sold.
- 17 institutional investors held Ensysce Biosciences (ENSC) as of Q4 2025, unchanged from Q3 2025.
- Funds reported $461K of Ensysce Biosciences stock for Q4 2025, down 45% quarter-over-quarter.
- 5 funds opened new Ensysce Biosciences positions in Q4 2025 and 5 closed out, a net change of 0 holders.
- The largest Ensysce Biosciences buyer in Q4 2025 was Adage Capital Partners, an estimated $139K added.
- The largest Ensysce Biosciences seller in Q4 2025 was Renaissance Technologies, an estimated $36.9K sold.
Based on aggregated 13F filings for Q4 2025.