|
1
|
Opera Trading Capital
Paris,
France
|
$1.44M
|
+$1.31M
|
+59,930
|
New
|
|
|
2
|
Claro Advisors
Boston,
Massachusetts
|
$9K
|
+$11K
|
+500
|
New
|
|
|
3
|
RA Capital Management
Boston,
Massachusetts
|
–
|
-$110M
|
-6,196,143
|
Closed
|
|
|
4
|
Avoro Capital Advisors
New York
|
–
|
-$94.2M
|
-5,301,718
|
Closed
|
|
|
5
|
|
–
|
-$93.7M
|
-5,274,121
|
Closed
|
|
|
6
|
VHCP Management II
New York
|
–
|
-$74.8M
|
-4,211,302
|
Closed
|
|
|
7
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-$62.6M
|
-3,524,390
|
Closed
|
|
|
8
|
Deerfield Management
New York
|
–
|
-$62.4M
|
-3,514,084
|
Closed
|
|
|
9
|
T. Rowe Price Associates
Baltimore,
Maryland
|
–
|
-$57.9M
|
-3,261,891
|
Closed
|
|
|
10
|
Baker Bros. Advisors
New York
|
–
|
-$45.3M
|
-2,548,069
|
Closed
|
|
|
11
|
Perceptive Advisors
New York
|
–
|
-$43.4M
|
-2,441,700
|
Closed
|
|
|
12
|
Point72 Asset Management
Stamford,
Connecticut
|
–
|
-$37.4M
|
-2,106,849
|
Closed
|
|
|
13
|
Janus Henderson Group
London,
|
–
|
-$31.2M
|
-1,758,435
|
Closed
|
|
|
14
|
State Street
Boston,
Massachusetts
|
–
|
-$28.7M
|
-1,616,058
|
Closed
|
|
|
15
|
Great Point Partners
Greenwich,
Connecticut
|
–
|
-$28.5M
|
-1,606,100
|
Closed
|
|
|
16
|
Citadel Advisors
Miami,
Florida
|
–
|
-$24.2M
|
-1,361,949
|
Closed
|
|
|
17
|
|
–
|
-$24M
|
-1,350,481
|
Closed
|
|
|
18
|
Eventide Asset Management
Boston,
Massachusetts
|
–
|
-$23.3M
|
-1,314,000
|
Closed
|
|
|
19
|
Adage Capital Partners
Boston,
Massachusetts
|
–
|
-$21.3M
|
-1,200,000
|
Closed
|
|
|
20
|
Ghost Tree Capital
New York
|
–
|
-$19.5M
|
-1,100,000
|
Closed
|
|
|
21
|
Fidelity Investments
Boston,
Massachusetts
|
–
|
-$16.1M
|
-907,057
|
Closed
|
|
|
22
|
Rock Springs Capital Management
Baltimore,
Maryland
|
–
|
-$15.1M
|
-850,000
|
Closed
|
|
|
23
|
Schonfeld Strategic Advisors
New York
|
–
|
-$14.6M
|
-822,100
|
Closed
|
|
|
24
|
Northern Trust
Chicago,
Illinois
|
–
|
-$14.2M
|
-797,888
|
Closed
|
|
|
25
|
Geode Capital Management
Boston,
Massachusetts
|
–
|
-$11.9M
|
-670,451
|
Closed
|
|
