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Day One Biopharmaceuticals

174 hedge funds and large institutions have $560M invested in Day One Biopharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 26 funds opening new positions, 71 increasing their positions, 56 reducing their positions, and 34 closing their positions.

New
Increased
Maintained
Reduced
Closed

more call options, than puts

Call options by funds: $ | Put options by funds: $

more repeat investments, than reductions

Existing positions increased: | Existing positions reduced:

less funds holding

Funds holding:

less ownership

Funds ownership:

24% less first-time investments, than exits

New positions opened: 26 | Existing positions closed: 34

25% less capital invested

Capital invested by funds: $746M → $560M (-$186M)

50% less funds holding in top 10

Funds holding in top 10: 21 (-1)

Holders
174
Holders Change
Holders Change %
% of All Funds
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
Increased
Reduced
Closed
Calls
$902K
Puts
$581K
Net Calls
Net Calls Change

Top Buyers

1 +$20M
2 +$4.96M
3 +$4.31M
4
Renaissance Technologies
Renaissance Technologies
New York
+$4.24M
5
Morgan Stanley
Morgan Stanley
New York
+$4.18M
Name Holding Trade Value Shares
Change
Change in
Stake
SPA
101
Sherbrooke Park Advisers
New York
$162K
CC
102
Corton Capital
Ontario, Canada
$159K
XT
103
XTX Topco
Cayman Islands
$158K
Cetera Investment Advisers
104
Cetera Investment Advisers
Illinois
$154K
Janus Henderson Group
105
Janus Henderson Group
United Kingdom
$139K
PA
106
Profund Advisors
Maryland
$136K
CUAMC
107
China Universal Asset Management Company
China
$132K
IWC
108
Integrated Wealth Concepts
Massachusetts
$131K
VOYA Investment Management
109
VOYA Investment Management
Georgia
$127K
PCM
110
Prelude Capital Management
New York
$127K
ASRS
111
Arizona State Retirement System
Arizona
$125K
ProShare Advisors
112
ProShare Advisors
Maryland
$121K
Creative Planning
113
Creative Planning
Kansas
$120K
Carson Wealth (CWM LLC)
114
Carson Wealth (CWM LLC)
Nebraska
$118K
State Board of Administration of Florida Retirement System
115
State Board of Administration of Florida Retirement System
Florida
$116K
OF
116
Optimize Financial
California
$116K
Teacher Retirement System of Texas
117
Teacher Retirement System of Texas
Texas
$115K
PFSRSONJ
118
Police & Firemen's Retirement System of New Jersey
New Jersey
$115K
A
119
AlphaQuest
New York
$103K
Cerity Partners
120
Cerity Partners
New York
$93.7K
Lazard Asset Management
121
Lazard Asset Management
New York
$89K
New York State Common Retirement Fund
122
New York State Common Retirement Fund
New York
$78.9K
KK
123
KLP Kapitalforvaltning
Norway
$76.7K
VRS
124
Virginia Retirement Systems
Virginia
$76K
QCM
125
Quantinno Capital Management
New York
$73.3K