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Day One Biopharmaceuticals
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Overview Fund Activity

174 hedge funds and large institutions have $560M invested in Day One Biopharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 26 funds opening new positions, 71 increasing their positions, 56 reducing their positions, and 34 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
174
Holders Change
-10
Holders Change %
-5.43%
% of All Funds
2.33%
Holding in Top 10
1
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-50%
% of All Funds
0.01%
New
26
Increased
71
Reduced
56
Closed
34
Calls
$902K
Puts
$581K
Net Calls
+$321K
Net Calls Change
+$855K

Top Buyers

1
BlackRock
1
BlackRock
New York
$63.9M
2
DM
2
Deerfield Management
New York
$24.2M
3
Qube Research & Technologies (QRT)
3
Qube Research & Technologies (QRT)
United Kingdom
$6.14M
4
Renaissance Technologies
4
Renaissance Technologies
New York
$6.5M
5
Morgan Stanley
5
Morgan Stanley
New York
$8.8M

Top Sellers

1
RCM
1
RA Capital Management
Massachusetts
$0
2
ECM
2
Estuary Capital Management
Minnesota
$0
3
Fidelity Investments
3
Fidelity Investments
Massachusetts
$73.7M
4
BCM
4
Boxer Capital Management
California
$0
5
B
5
Braidwell
Connecticut
$14.2M
Name Holding Trade Value Shares
Change 		Shares
Change %
Citadel Advisors
26
Citadel Advisors
Florida
$4.57M -$4.13M -635,374 -47%
Northern Trust
27
Northern Trust
Illinois
$3.97M +$489K +75,164 +14%
Charles Schwab
28
Charles Schwab
California
$3.76M +$329K +50,615 +10%
JGC
29
J. Goldman & Co
New York
$3.62M +$3.62M +557,480 New
PHP
30
Parkman Healthcare Partners
Connecticut
$3.25M -$3.53M -543,162 -52%
KCM
31
Kennedy Capital Management
Missouri
$2.95M +$818K +125,829 +38%
SCM
32
Stonepine Capital Management
Oregon
$2.93M +$658K +101,180 +29%
Point72 Asset Management
33
Point72 Asset Management
Connecticut
$2.54M +$2.54M +391,280 New
Barclays
34
Barclays
United Kingdom
$2.26M +$1.25M +192,900 +124%
Deutsche Bank
35
Deutsche Bank
Germany
$2.11M -$60K -9,234 -3%
ECM
36
ExodusPoint Capital Management
New York
$2.08M +$1.93M +296,480 +1,249%
Bank of New York Mellon
37
Bank of New York Mellon
New York
$2M +$387K +59,473 +24%
YIH
38
Y-Intercept (HK)
Hong Kong
$1.83M +$1.83M +281,528 New
AQR Capital Management
39
AQR Capital Management
Connecticut
$1.82M -$2.2M -338,777 -55%
PL
40
Parkwood LLC
Ohio
$1.79M – – –
SFI
41
Susquehanna Fundamental Investments
Pennsylvania
$1.71M -$387K -59,562 -18%
Fisher Asset Management
42
Fisher Asset Management
Washington
$1.44M -$346K -53,224 -19%
CSS
43
Cubist Systematic Strategies
Connecticut
$1.26M +$1.26M +193,857 New
Schroder Investment Management Group
44
Schroder Investment Management Group
United Kingdom
$1.17M +$1.17M +180,133 New
UBS AM
45
UBS AM
Illinois
$1.14M +$410K +63,137 +56%
SFM
46
Sphera Funds Management
Israel
$1.14M -$1.04M -159,616 -48%
Royal Bank of Canada
47
Royal Bank of Canada
Ontario, Canada
$1.14M -$69.9K -10,759 -6%
Norges Bank
48
Norges Bank
Norway
$1.1M +$1.1M +169,000 New
NL
49
Nuveen LLC
North Carolina
$977K +$69.6K +10,714 +8%
Russell Investments Group
50
Russell Investments Group
United Kingdom
$932K +$826K +127,113 +778%
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