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Day One Biopharmaceuticals
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Overview Fund Activity

184 hedge funds and large institutions have $746M invested in Day One Biopharmaceuticals in 2025 Q1 according to their latest regulatory filings, with 43 funds opening new positions, 69 increasing their positions, 45 reducing their positions, and 22 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
184
Holders Change
+20
Holders Change %
+12.2%
% of All Funds
2.5%
Holding in Top 10
2
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.03%
New
43
Increased
69
Reduced
45
Closed
22
Calls
$1.23M
Puts
$1.76M
Net Calls
-$534K
Net Calls Change
+$741K

Top Buyers

1
PCH
Polar Capital Holdings
United Kingdom
$18.6M
2
Alyeska Investment Group
Alyeska Investment Group
Illinois
$32.2M
3
VPC
Vestal Point Capital
New York
$20.6M
4
Millennium Management
Millennium Management
New York
$10.5M
5
Goldman Sachs
Goldman Sachs
New York
$12.4M

Top Sellers

1
FFM
Fairmount Funds Management
Pennsylvania
$0
2
TCM
TimesSquare Capital Management
New York
$0
3
FTM
First Turn Management
California
$0
4
B
Braidwell
Connecticut
$28M
5
Janus Henderson Group
Janus Henderson Group
United Kingdom
$172K
Name Holding Trade Value Shares
Change 		Shares
Change %
EC
26
EcoR1 Capital
California
$6.84M – – –
DCM
27
DAFNA Capital Management
California
$5.8M – – –
Morgan Stanley
28
Morgan Stanley
New York
$5.63M -$2.94M -370,853 -34%
AQR Capital Management
29
AQR Capital Management
Connecticut
$4.91M +$4.21M +530,429 +601%
Northern Trust
30
Northern Trust
Illinois
$4.25M -$87.7K -11,053 -2%
Charles Schwab
31
Charles Schwab
California
$4.19M -$58.3K -7,353 -1%
AG
32
Algert Global
California
$2.95M +$2.95M +371,380 New
SCM
33
Stonepine Capital Management
Oregon
$2.77M +$903K +113,820 +48%
Renaissance Technologies
34
Renaissance Technologies
New York
$2.76M +$830K +104,700 +43%
SFM
35
Sphera Funds Management
Israel
$2.66M – – –
Deutsche Bank
36
Deutsche Bank
Germany
$2.65M -$193K -24,398 -7%
KCM
37
Kennedy Capital Management
Missouri
$2.6M +$1.06M +133,779 +69%
SFI
38
Susquehanna Fundamental Investments
Pennsylvania
$2.56M +$2.56M +322,875 New
Qube Research & Technologies (QRT)
39
Qube Research & Technologies (QRT)
United Kingdom
$2.23M +$762K +96,128 +52%
Fisher Asset Management
40
Fisher Asset Management
Washington
$2.18M +$1.48M +186,075 +209%
PL
41
Parkwood LLC
Ohio
$2.18M – – –
Bank of New York Mellon
42
Bank of New York Mellon
New York
$1.97M +$28.2K +3,551 +1%
WP
43
Woodline Partners
California
$1.69M -$4.65M -585,771 -73%
TI
44
Trexquant Investment
Connecticut
$1.62M +$926K +116,810 +133%
Royal Bank of Canada
45
Royal Bank of Canada
Ontario, Canada
$1.47M +$424K +53,459 +40%
Citigroup
46
Citigroup
New York
$1.31M +$66.9K +8,442 +5%
BNP Paribas Financial Markets
47
BNP Paribas Financial Markets
France
$1.28M +$994K +125,319 +342%
Barclays
48
Barclays
United Kingdom
$1.23M +$109K +13,757 +10%
NL
49
Nuveen LLC
North Carolina
$1.11M +$1.11M +139,658 New
HWAM
50
Hennion & Walsh Asset Management
New Jersey
$1.09M +$133K +16,801 +14%
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