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Castle Biosciences

180 hedge funds and large institutions have $516M invested in Castle Biosciences in 2025 Q1 according to their latest regulatory filings, with 29 funds opening new positions, 77 increasing their positions, 54 reducing their positions, and 44 closing their positions.

New
Increased
Maintained
Reduced
Closed

79% more call options, than puts

Call options by funds: $200K | Put options by funds: $112K

43% more repeat investments, than reductions

Existing positions increased: 77 | Existing positions reduced: 54

0% more funds holding in top 10

Funds holding in top 10: 22 (0)

3.89% less ownership

Funds ownership: 94.63%90.74% (-3.9%)

9% less funds holding

Funds holding: 197180 (-17)

27% less capital invested

Capital invested by funds: $706M → $516M (-$190M)

34% less first-time investments, than exits

New positions opened: 29 | Existing positions closed: 44

Holders
180
Holders Change
-17
Holders Change %
-8.63%
% of All Funds
2.41%
Holding in Top 10
2
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.03%
New
29
Increased
77
Reduced
54
Closed
44
Calls
$200K
Puts
$112K
Net Calls
+$88K
Net Calls Change
-$2.62M
Name Holding Trade Value Shares
Change
Change in
Stake
PCM
76
Perkins Capital Management
Minnesota
$680K -$4.95K -200 -0.6%
AllianceBernstein
77
AllianceBernstein
Tennessee
$668K
Invesco
78
Invesco
Georgia
$646K +$117K +4,717 +17%
Jane Street
79
Jane Street
New York
$614K -$711K -28,707 -48%
Verition Fund Management
80
Verition Fund Management
Connecticut
$614K +$535K +21,623 +239%
SGI
81
Summit Global Investments
Utah
$613K +$53.6K +2,164 +8%
JP Morgan Chase
82
JP Morgan Chase
New York
$612K -$1.92M -77,359 -72%
HF
83
HRT Financial
New York
$566K +$394K +15,916 +129%
PA
84
Parallel Advisors
California
$551K -$9.95K -402 -1%
Mackenzie Financial
85
Mackenzie Financial
Ontario, Canada
$550K +$159K +6,440 +31%
Legal & General Group
86
Legal & General Group
United Kingdom
$519K -$891 -36 -0.1%
California State Teachers Retirement System (CalSTRS)
87
California State Teachers Retirement System (CalSTRS)
California
$493K
TC
88
TownSquare Capital
Utah
$476K +$39.2K +1,584 +7%
T. Rowe Price Associates
89
T. Rowe Price Associates
Maryland
$475K +$25K +1,008 +4%
YF
90
Yu Fan
$451K
Truist Financial
91
Truist Financial
North Carolina
$447K +$24.9K +1,005 +5%
Jacobs Levy Equity Management
92
Jacobs Levy Equity Management
New Jersey
$426K -$2.81M -113,483 -84%
DTL
93
Dynamic Technology Lab
Singapore
$425K +$89.3K +3,605 +20%
Cerity Partners
94
Cerity Partners
New York
$423K +$523K +21,138 New
HSA
95
Hussman Strategic Advisors
Maryland
$420K -$1.3M -52,500 -71%
EC
96
EntryPoint Capital
New York
$409K -$216K -8,712 -30%
AACP
97
Advantage Alpha Capital Partners
California
$396K +$490K +19,805 New
Balyasny Asset Management
98
Balyasny Asset Management
Illinois
$395K +$488K +19,730 New
XT
99
XTX Topco
Cayman Islands
$393K +$486K +19,628 New
HSBC Holdings
100
HSBC Holdings
United Kingdom
$391K -$1.14K -46 -0.2%

CSTL Hedge Fund Activity: Q1 2025 in Review

180 of the 7,458 institutional investors tracked by Wall St. Rank reported a position in Castle Biosciences (CSTL) for Q1 2025, worth a combined $516M — down 27% from $706M a quarter earlier.

Sellers outnumbered buyers: 44 funds closed out of CSTL and 29 opened new positions — a net loss of 15 holders — while 54 trimmed existing stakes and 77 added.

The largest buyer was Schroder Investment Management Group, opening a new position worth an estimated $14.8M. The largest seller was Wasatch Advisors, cutting an estimated $19.7M.

  • 180 institutional investors held Castle Biosciences (CSTL) as of Q1 2025, down from 197 in Q4 2024.
  • Funds reported $516M of Castle Biosciences stock for Q1 2025, down 27% quarter-over-quarter.
  • 29 funds opened new Castle Biosciences positions in Q1 2025 and 44 closed out, a net change of -15 holders.
  • The largest Castle Biosciences buyer in Q1 2025 was Schroder Investment Management Group, an estimated $14.8M added.
  • The largest Castle Biosciences seller in Q1 2025 was Wasatch Advisors, an estimated $19.7M sold.

Based on aggregated 13F filings for Q1 2025.