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CLSD

Clearside Biomedical
CLSD

Delisted

CLSD was delisted on the 28th of November, 2025.

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67 hedge funds and large institutions have $57.8M invested in Clearside Biomedical in 2021 Q4 according to their latest regulatory filings, with 19 funds opening new positions, 22 increasing their positions, 14 reducing their positions, and 16 closing their positions.

New
Increased
Maintained
Reduced
Closed

68% more call options, than puts

Call options by funds: $2.48M | Put options by funds: $1.48M

57% more repeat investments, than reductions

Existing positions increased: 22 | Existing positions reduced: 14

19% more first-time investments, than exits

New positions opened: 19 | Existing positions closed: 16

3% more funds holding

Funds holding: 65 → 67 (+2)

0.08% more ownership

Funds ownership: 2.27% → 2.35% (+0.08%)

52% less capital invested

Capital invested by funds: $122M → $57.8M (-$63.7M)

67% less funds holding in top 10

Funds holding in top 10: 3 → 1 (-2)

Holders
67
Holders Change
+2
Holders Change %
+3.08%
% of All Funds
1.03%
Holding in Top 10
1
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-66.67%
% of All Funds
0.02%
New
19
Increased
22
Reduced
14
Closed
16
Calls
$2.48M
Puts
$1.48M
Net Calls
+$1.01M
Net Calls Change
-$478K

Top Buyers

Rank Fund Capital Flow
1
Assenagon Asset Management
Assenagon Asset Management
Luxembourg
+$6.98M
2
Morgan Stanley
Morgan Stanley
New York
+$3.45M
3
BlackRock
BlackRock
New York
+$1.79M
4
Renaissance Technologies
Renaissance Technologies
New York
+$1.42M
5
Group One Trading
Group One Trading
Illinois
+$581K

Top Sellers

Rank Fund Capital Flow
1
ACP
Acuta Capital Partners
California
-$7.9M
2
AIIC
AJU IB Investment Company
South Korea
-$1.76M
3
RI
RTW Investments
New York
-$1.73M
4
Invesco
Invesco
Georgia
-$1.66M
5
EI
EAM Investors
California
-$1.49M
Name Holding Trade Value Shares
Change 		Change in
Stake
RI
1
RTW Investments
New York
$10.5M -$1.73M -26,716 -10%
CG
2
Carmignac Gestion
France
$6.84M +$43.2K +667 +0.4%
ACM
3
ACT Capital Management
Pennsylvania
$6.83M +$69.1K +1,067 +0.6%
Vanguard Group
4
Vanguard Group
Pennsylvania
$5.98M -$13K -201 -0.1%
Assenagon Asset Management
5
Assenagon Asset Management
Luxembourg
$4.5M +$6.98M +107,703 +8,561%
Morgan Stanley
6
Morgan Stanley
New York
$4.42M +$3.45M +53,324 +99%
BlackRock
7
BlackRock
New York
$3.35M +$1.79M +27,670 +52%
Two Sigma Investments
8
Two Sigma Investments
New York
$2.59M +$487K +7,520 +14%
Two Sigma Advisers
9
Two Sigma Advisers
New York
$2.42M -$568K -8,767 -13%
Geode Capital Management
10
Geode Capital Management
Massachusetts
$1.34M – – –
Renaissance Technologies
11
Renaissance Technologies
New York
$1.18M +$1.42M +21,848 +323%
Millennium Management
12
Millennium Management
New York
$1.02M +$454K +7,002 +40%
BCM
13
Bridgeway Capital Management
Texas
$871K – – –
Susquehanna International Group
14
Susquehanna International Group
Pennsylvania
$761K -$432K -6,664 -27%
State Street
15
State Street
Massachusetts
$506K – – –
First Manhattan
16
First Manhattan
New York
$481K – – –
Group One Trading
17
Group One Trading
Illinois
$448K +$581K +8,977 +478%
Franklin Resources
18
Franklin Resources
California
$307K -$1.23K -19 -0.3%
Walleye Capital
19
Walleye Capital
New York
$285K +$448K +6,918 New
Northern Trust
20
Northern Trust
Illinois
$266K -$27.9K -430 -6%
Goldman Sachs
21
Goldman Sachs
New York
$219K +$141K +2,176 +70%
JF
22
Jump Financial
Illinois
$187K +$129K +1,987 +78%
Principal Financial Group
23
Principal Financial Group
Iowa
$180K +$282K +4,356 New
S
24
SignatureFD
Georgia
$149K -$1.23K -19 -0.5%
CSS
25
Cubist Systematic Strategies
Connecticut
$146K -$117K -1,801 -34%
1
2 3 4

CLSD Hedge Fund Activity: Q4 2021 in Review

67 of the 6,498 institutional investors tracked by Wall St. Rank reported a position in Clearside Biomedical (CLSD) for Q4 2021, worth a combined $57.8M — down 52% from $122M a quarter earlier.

Buyers outnumbered sellers: 19 funds opened new CLSD positions and 16 closed out — a net gain of 3 holders — while 22 added to existing stakes and 14 trimmed.

The largest buyer was Assenagon Asset Management, adding an estimated $6.98M. The largest seller was Acuta Capital Partners, exiting entirely with an estimated $7.9M sold.

  • 67 institutional investors held Clearside Biomedical (CLSD) as of Q4 2021, up from 65 in Q3 2021.
  • Funds reported $57.8M of Clearside Biomedical stock for Q4 2021, down 52% quarter-over-quarter.
  • 19 funds opened new Clearside Biomedical positions in Q4 2021 and 16 closed out, a net change of +3 holders.
  • The largest Clearside Biomedical buyer in Q4 2021 was Assenagon Asset Management, an estimated $6.98M added.
  • The largest Clearside Biomedical seller in Q4 2021 was Acuta Capital Partners, an estimated $7.9M sold.

Based on aggregated 13F filings for Q4 2021.