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CareDx
CDNA

200 hedge funds and large institutions have $983M invested in CareDx in 2025 Q4 according to their latest regulatory filings, with 41 funds opening new positions, 63 increasing their positions, 64 reducing their positions, and 27 closing their positions.

New
Increased
Maintained
Reduced
Closed

43,375% more call options, than puts

Call options by funds: $1.74M | Put options by funds: $4K

52% more first-time investments, than exits

New positions opened: 41 | Existing positions closed: 27

26% more capital invested

Capital invested by funds: $779M → $983M (+$204M)

7% more funds holding

Funds holding: 187 → 200 (+13)

0.77% more ownership

Funds ownership: 100.65% → 101.42% (+0.77%)

2% less repeat investments, than reductions

Existing positions increased: 63 | Existing positions reduced: 64

20% less funds holding in top 10

Funds holding in top 10: 5 → 4 (-1)

Holders
200
Holders Change
+13
Holders Change %
+6.95%
% of All Funds
2.43%
Holding in Top 10
4
Holding in Top 10 Change
-1
Holding in Top 10 Change %
-20%
% of All Funds
0.05%
New
41
Increased
63
Reduced
64
Closed
27
Calls
$1.74M
Puts
$4K
Net Calls
+$1.74M
Net Calls Change
+$1.09M

Top Buyers

1
Boston Partners
Boston Partners
Massachusetts
+$14.6M
2
D.E. Shaw & Co
D.E. Shaw & Co
New York
+$7.44M
3
Aberdeen Group
Aberdeen Group
United Kingdom
+$5.78M
4
Chevy Chase Trust
Chevy Chase Trust
Maryland
+$5.66M
5
Jane Street
Jane Street
New York
+$5.65M

Top Sellers

1
OAM
Ophir Asset Management
Australia
-$21.3M
2
FAM
Fred Alger Management
New York
-$12.6M
3
B
Braidwell
Connecticut
-$10M
4
Connor, Clark & Lunn Investment Management (CC&L)
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
-$6.78M
5
Macquarie Group
Macquarie Group
Australia
-$6.73M
Name Holding Trade Value Shares
Change 		Change in
Stake
Bank of New York Mellon
51
Bank of New York Mellon
New York
$3.2M +$254K +15,139 +10%
Wellington Management Group
52
Wellington Management Group
Massachusetts
$3.2M -$247K -14,749 -8%
Barclays
53
Barclays
United Kingdom
$3.1M -$377K -22,482 -12%
Raymond James Financial
54
Raymond James Financial
Florida
$3.05M -$80.3K -4,792 -3%
State Board of Administration of Florida Retirement System
55
State Board of Administration of Florida Retirement System
Florida
$2.63M +$2.02M +120,727 +645%
UBS AM
56
UBS AM
Illinois
$2.36M -$263K -15,729 -11%
State of Wisconsin Investment Board
57
State of Wisconsin Investment Board
Wisconsin
$2.36M -$732K -43,717 -26%
EGM
58
Engineers Gate Manager
New York
$2.27M +$361K +21,530 +22%
UBS Group
59
UBS Group
Switzerland
$2.26M +$144K +8,572 +8%
Lazard Asset Management
60
Lazard Asset Management
New York
$2.19M -$168K -10,033 -8%
Invesco
61
Invesco
Georgia
$2.18M +$96.5K +5,758 +5%
Franklin Resources
62
Franklin Resources
California
$1.95M +$63.2K +3,774 +4%
Two Sigma Advisers
63
Two Sigma Advisers
New York
$1.93M +$1.24M +74,200 +264%
JF
64
Jump Financial
Illinois
$1.9M +$1.14M +67,849 +205%
FG
65
Formula Growth
Quebec, Canada
$1.9M -$1.53M -91,625 -48%
Balyasny Asset Management
66
Balyasny Asset Management
Illinois
$1.88M +$1M +59,748 +149%
Millennium Management
67
Millennium Management
New York
$1.88M -$5.26M -313,954 -76%
Swiss National Bank
68
Swiss National Bank
Switzerland
$1.88M -$46.9K -2,800 -3%
AIP
69
ARS Investment Partners
New York
$1.78M -$196K -11,716 -11%
Rafferty Asset Management
70
Rafferty Asset Management
New York
$1.72M -$22.9K -1,364 -1%
Two Sigma Investments
71
Two Sigma Investments
New York
$1.68M +$1.5M +89,300 New
American Century Companies
72
American Century Companies
Missouri
$1.65M +$268K +15,988 +22%
IEFM
73
IQ EQ Fund Management
Ireland
$1.57M +$423K +25,231 +43%
GAM
74
Gotham Asset Management
New York
$1.56M +$1.38M +82,593 New
GC
75
Globeflex Capital
California
$1.5M +$147K +8,792 +12%
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CDNA Hedge Fund Activity: Q4 2025 in Review

200 of the 8,223 institutional investors tracked by Wall St. Rank reported a position in CareDx (CDNA) for Q4 2025, worth a combined $983M — up 26% from $779M a quarter earlier.

Buyers outnumbered sellers: 41 funds opened new CDNA positions and 27 closed out — a net gain of 14 holders — while 63 added to existing stakes and 64 trimmed.

The largest buyer was Boston Partners, adding an estimated $14.6M. The largest seller was Ophir Asset Management, cutting an estimated $21.3M.

  • 200 institutional investors held CareDx (CDNA) as of Q4 2025, up from 187 in Q3 2025.
  • Funds reported $983M of CareDx stock for Q4 2025, up 26% quarter-over-quarter.
  • 41 funds opened new CareDx positions in Q4 2025 and 27 closed out, a net change of +14 holders.
  • The largest CareDx buyer in Q4 2025 was Boston Partners, an estimated $14.6M added.
  • The largest CareDx seller in Q4 2025 was Ophir Asset Management, an estimated $21.3M sold.

Based on aggregated 13F filings for Q4 2025.