|
1
|
Polaris Venture Management Co V
Boston,
Massachusetts
|
$24.1M
|
+$26.4M
|
+2,018,253
|
New
|
|
|
2
|
Opaleye Management
Boston,
Massachusetts
|
$5.11M
|
+$3.55M
|
+272,000
|
+175%
|
|
|
3
|
Franklin Resources
San Mateo,
California
|
$4.33M
|
+$299K
|
+22,900
|
+7%
|
|
|
4
|
Principal Financial Group
Des Moines,
Iowa
|
$3.7M
|
-$53.7K
|
-4,115
|
-1%
|
|
|
5
|
Putnam Investments
Boston,
Massachusetts
|
$2.92M
|
-$730K
|
-55,900
|
-19%
|
|
|
6
|
BlackRock Fund Advisors
San Francisco,
California
|
$1.82M
|
+$150K
|
+11,476
|
+8%
|
|
|
7
|
Vanguard Group
Malvern,
Pennsylvania
|
$1.69M
|
+$1.05M
|
+80,383
|
+132%
|
|
|
8
|
BlackRock Advisors
Wilmington,
Delaware
|
$1.57M
|
+$1.54M
|
+117,605
|
+854%
|
|
|
9
|
BVF Inc
San Francisco,
California
|
$1.39M
|
-$444K
|
-34,000
|
-23%
|
|
|
10
|
Millennium Management
New York
|
$1.38M
|
+$558K
|
+42,698
|
+59%
|
|
|
11
|
BlackRock Institutional Trust
San Francisco,
California
|
$965K
|
-$5.94K
|
-455
|
-0.6%
|
|
|
12
|
Northern Trust
Chicago,
Illinois
|
$810K
|
-$95.9K
|
-7,345
|
-10%
|
|
|
13
|
Rhenman & Partners Asset Management
Stockholm,
Sweden
|
$718K
|
+$784K
|
+60,000
|
New
|
|
|
14
|
State Street
Boston,
Massachusetts
|
$591K
|
+$192K
|
+14,711
|
+42%
|
|
|
15
|
Credit Suisse
Zurich,
Switzerland
|
$535K
|
-$300K
|
-22,986
|
-34%
|
|
|
16
|
Emerald Advisers
Leola,
Pennsylvania
|
$504K
|
-$4.93M
|
-377,629
|
-90%
|
|
|
17
|
SSI Investment Management
Los Angeles,
California
|
$394K
|
+$122K
|
+9,375
|
+40%
|
|
|
18
|
Raymond James & Associates
St Petersburg,
Florida
|
$392K
|
-$8.62K
|
-660
|
-2%
|
|
|
19
|
Geode Capital Management
Boston,
Massachusetts
|
$384K
|
+$21K
|
+1,605
|
+5%
|
|
|
20
|
TFS Capital
West Chester,
Pennsylvania
|
$279K
|
+$31.5K
|
+2,414
|
+12%
|
|
|
21
|
Bank of New York Mellon
New York
|
$258K
|
+$281K
|
+21,525
|
New
|
|
|
22
|
Emerald Mutual Fund Advisers Trust
Leola,
Pennsylvania
|
$231K
|
-$3.48M
|
-266,254
|
-93%
|
|
|
23
|
TIAA CREF Investment Management
New York
|
$220K
|
+$53.5K
|
+4,100
|
+29%
|
|
|
24
|
BlackRock Investment Management
Wilmington,
Delaware
|
$186K
|
+$39K
|
+2,983
|
+24%
|
|
|
25
|
Banque Pictet & Cie
Geneva 73,
Switzerland
|
$164K
|
+$179K
|
+13,740
|
New
|
|
