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Apellis Pharmaceuticals
APLS

Overview Fund Activity

246 hedge funds and large institutions have $2.28B invested in Apellis Pharmaceuticals in 2025 Q2 according to their latest regulatory filings, with 43 funds opening new positions, 108 increasing their positions, 69 reducing their positions, and 49 closing their positions.

New
Increased
Maintained
Reduced
Closed
Holders
246
Holders Change
-8
Holders Change %
-3.15%
% of All Funds
3.3%
Holding in Top 10
4
Holding in Top 10 Change
-2
Holding in Top 10 Change %
-33.33%
% of All Funds
0.05%
New
43
Increased
108
Reduced
69
Closed
49
Calls
$56.2M
Puts
$12.6M
Net Calls
+$43.6M
Net Calls Change
+$36.9M

Top Buyers

1
Marshall Wace
1
Marshall Wace
United Kingdom
$46.8M
2
DTC
2
Deep Track Capital
Connecticut
$121M
3
AQR Capital Management
3
AQR Capital Management
Connecticut
$103M
4
UBS Group
4
UBS Group
Switzerland
$82M
5
Amundi
5
Amundi
France
$28.6M

Top Sellers

1
Wellington Management Group
1
Wellington Management Group
Massachusetts
$155M
2
Fidelity Investments
2
Fidelity Investments
Massachusetts
$334K
3
Man Group
3
Man Group
United Kingdom
$0
4
OCA
4
Octagon Capital Advisors
New York
$15.6M
5
National Bank of Canada
5
National Bank of Canada
Quebec, Canada
$0
Name Holding Trade Value Shares
Change 		Shares
Change %
ACA
1
Avoro Capital Advisors
New York
$212M – – –
EC
2
EcoR1 Capital
California
$206M – – –
Vanguard Group
3
Vanguard Group
Pennsylvania
$176M +$422K +24,395 +0.2%
Morgan Stanley
4
Morgan Stanley
New York
$169M +$2.18M +126,078 +1%
Wellington Management Group
5
Wellington Management Group
Massachusetts
$155M -$57.6M -3,326,290 -27%
DTC
6
Deep Track Capital
Connecticut
$121M +$34.6M +2,000,000 +40%
BlackRock
7
BlackRock
New York
$111M +$1.31M +75,401 +1%
AQR Capital Management
8
AQR Capital Management
Connecticut
$103M +$32.9M +1,898,995 +47%
UBS Group
9
UBS Group
Switzerland
$82M +$25.3M +1,463,117 +45%
State Street
10
State Street
Massachusetts
$61.7M -$6.56M -378,684 -10%
SCM
11
Suvretta Capital Management
New York
$49.8M +$21.3M +1,231,385 +75%
Marshall Wace
12
Marshall Wace
United Kingdom
$46.8M +$46.4M +2,681,263 +11,374%
Jennison Associates
13
Jennison Associates
New York
$46.1M +$3.19M +184,292 +7%
SL
14
Siren LLC
Connecticut
$44.6M – – –
Bank of America
15
Bank of America
North Carolina
$42M -$12.2M -704,808 -23%
Norges Bank
16
Norges Bank
Norway
$41M +$41M +2,367,224 New
Geode Capital Management
17
Geode Capital Management
Massachusetts
$34.5M +$783K +45,225 +2%
Amundi
18
Amundi
France
$28.6M +$22.7M +1,274,523 +387%
Deutsche Bank
19
Deutsche Bank
Germany
$25.9M -$4.85M -280,280 -16%
O
20
OrbiMed
New York
$25.7M +$866K +50,000 +3%
PCH
21
Polar Capital Holdings
United Kingdom
$23.4M -$3.89M -225,000 -14%
BNP Paribas Financial Markets
22
BNP Paribas Financial Markets
France
$22.5M +$3.25M +187,750 +17%
B
23
Braidwell
Connecticut
$19.4M -$9.2M -531,300 -32%
Wells Fargo
24
Wells Fargo
California
$18.1M +$18M +1,039,031 +22,470%
Charles Schwab
25
Charles Schwab
California
$17.1M +$427K +24,644 +3%
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