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Annovis Bio
ANVS

53 hedge funds and large institutions have $14.7M invested in Annovis Bio in 2025 Q4 according to their latest regulatory filings, with 20 funds opening new positions, 17 increasing their positions, 2 reducing their positions, and 8 closing their positions.

New
Increased
Maintained
Reduced
Closed

750% more repeat investments, than reductions

Existing positions increased: 17 | Existing positions reduced: 2

250% more capital invested

Capital invested by funds: $4.19M → $14.7M (+$10.5M)

162% more call options, than puts

Call options by funds: $2.01M | Put options by funds: $768K

150% more first-time investments, than exits

New positions opened: 20 | Existing positions closed: 8

26% more funds holding

Funds holding: 42 → 53 (+11)

5.6% more ownership

Funds ownership: 10.39% → 15.99% (+5.6%)

Holders
53
Holders Change
+11
Holders Change %
+26.19%
% of All Funds
0.64%
Holding in Top 10
–
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
–
New
20
Increased
17
Reduced
2
Closed
8
Calls
$2.01M
Puts
$768K
Net Calls
+$1.24M
Net Calls Change
+$1.05M

Top Buyers

Rank Fund Capital Flow
1
Marshall Wace
Marshall Wace
United Kingdom
+$2.18M
2
Two Sigma Investments
Two Sigma Investments
New York
+$1.66M
3
Jane Street
Jane Street
New York
+$755K
4
Vanguard Group
Vanguard Group
Pennsylvania
+$557K
5
DADC
D.A. Davidson & Co
Montana
+$483K

Top Sellers

Rank Fund Capital Flow
1
Citadel Advisors
Citadel Advisors
Florida
-$524K
2
HF
HRT Financial
New York
-$77K
3
XT
XTX Topco
Cayman Islands
-$59.7K
4
TSS
Two Sigma Securities
New York
-$21.8K
5
GWM
Greenwich Wealth Management
Connecticut
-$15K
Name Holding Trade Value Shares
Change 		Change in
Stake
WANY
26
Wealthspire Advisors (New York)
New York
$69.2K +$30.1K +10,000 +100%
GCP
27
Gill Capital Partners
Colorado
$64.3K +$55.8K +18,579 New
RSWM
28
Robertson Stephens Wealth Management
California
$64.3K +$55.8K +18,579 New
CAMG
29
CWA Asset Management Group
Florida
$58.8K +$12K +4,000 +31%
Koshinski Asset Management
30
Koshinski Asset Management
Illinois
$51.9K +$45.1K +15,010 New
JP Morgan Chase
31
JP Morgan Chase
New York
$51.6K – – –
Wells Fargo
32
Wells Fargo
California
$49.5K +$13.7K +4,561 +47%
TRCT
33
Tower Research Capital (TRC)
New York
$47.3K +$38K +12,641 +1,238%
RA
34
RFG Advisory
Alabama
$43.1K +$37.5K +12,461 New
RWM
35
RKL Wealth Management
Pennsylvania
$34.6K +$30.1K +10,000 New
Morgan Stanley
36
Morgan Stanley
New York
$34.3K +$7.55K +2,512 +34%
WSFS
37
Wilmington Savings Fund Society
Delaware
$32.5K – – –
C
38
Covestor
United Kingdom
$8K – – –
FIA
39
FNY Investment Advisers
New York
$6K – – –
SS
40
SBI Securities
Japan
$5.28K +$289 +96 +7%
DPW
41
DiNuzzo Private Wealth
Pennsylvania
$3.46K – – –
Rockefeller Capital Management
42
Rockefeller Capital Management
New York
$3.46K – – –
AAP
43
Arax Advisory Partners
Colorado
$3.46K +$3.01K +1,000 New
PNC Financial Services Group
44
PNC Financial Services Group
Pennsylvania
$1.25K – – –
RhumbLine Advisers
45
RhumbLine Advisers
Massachusetts
$1.21K – – –
LFG
46
Larson Financial Group
Missouri
$1.04K – – –
Royal Bank of Canada
47
Royal Bank of Canada
Ontario, Canada
$1K +$944 +314 New
IA
48
IFP Advisors
Florida
$727 – – –
Osaic Holdings
49
Osaic Holdings
Arizona
$727 – – –
Bank of America
50
Bank of America
North Carolina
$716 +$186 +62 +43%
1
2
3

ANVS Hedge Fund Activity: Q4 2025 in Review

53 of the 8,224 institutional investors tracked by Wall St. Rank reported a position in Annovis Bio (ANVS) for Q4 2025, worth a combined $14.7M — up 250% from $4.19M a quarter earlier.

Buyers outnumbered sellers: 20 funds opened new ANVS positions and 8 closed out — a net gain of 12 holders — while 17 added to existing stakes and 2 trimmed.

The largest buyer was Marshall Wace, opening a new position worth an estimated $2.18M. The largest seller was Citadel Advisors, exiting entirely with an estimated $524K sold.

  • 53 institutional investors held Annovis Bio (ANVS) as of Q4 2025, up from 42 in Q3 2025.
  • Funds reported $14.7M of Annovis Bio stock for Q4 2025, up 250% quarter-over-quarter.
  • 20 funds opened new Annovis Bio positions in Q4 2025 and 8 closed out, a net change of +12 holders.
  • The largest Annovis Bio buyer in Q4 2025 was Marshall Wace, an estimated $2.18M added.
  • The largest Annovis Bio seller in Q4 2025 was Citadel Advisors, an estimated $524K sold.

Based on aggregated 13F filings for Q4 2025.