Two Sigma Investments
ANVS icon

Two Sigma Investments’s Annovis Bio ANVS Stock Holding History

Two Sigma Investments’s Portfolio ANVS Stock Details ANVS Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.4M Buy
627,659
+75,822
+14% +$208K ﹤0.01% 3016
2025
Q4 		$1.91M Buy
+551,837
New +$1.66M ﹤0.01% 2470
2025
Q2 		– Sell
-166,219
Closed -$249K – 3169
2025
Q1 		$249K Buy
166,219
+155,296
+1,422% +$475K ﹤0.01% 2788
2024
Q4 		$54.9K Buy
+10,923
New +$79.1K ﹤0.01% 3035
2022
Q1 		– Sell
-51,747
Closed -$910K – 2660
2021
Q4 		$910K Sell
51,747
-45,819
-47% -$1.18M ﹤0.01% 2644
2021
Q3 		$3.1M Buy
+97,566
New +$5.61M 0.01% 1586

Other funds holding ANVS

Marshall Wace
Marshall Wace London, United Kingdom $100B AUM 35.1% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Renaissance Technologies
Renaissance Technologies New York $63.9B AUM 45.56% 1-Year Est. Return
Geode Capital Management
Geode Capital Management Boston, Massachusetts $1.61T AUM 30.72% 1-Year Est. Return
Susquehanna International Group
Susquehanna International Group Bala Cynwyd, Pennsylvania $893B AUM 36.07% 1-Year Est. Return
Northern Trust
Northern Trust Chicago, Illinois $757B AUM 28.64% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
VFT
Vanguard Fiduciary Trust Malvern, Pennsylvania $396B AUM
MFG
Merit Financial Group Alpharetta, Georgia $16.4B AUM 25.17% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's ANVS Position: Q1 2026 in Review

Two Sigma Investments increased its Annovis Bio (ANVS) stake by 14% in Q1 2026, buying an estimated $208K and bringing the position to 627,659 shares worth $1.4M. The position accounts for ﹤0.01% of the portfolio, ranked #3016.

Two Sigma Investments first reported a position in ANVS in Q3 2021 and has held it in 6 quarters since. The position peaked at $3.1M in Q3 2021. 56 funds tracked by Wall St. Rank hold ANVS as of Q1 2026.

  • Two Sigma Investments held 627,659 shares of Annovis Bio worth $1.4M as of Q1 2026.
  • Two Sigma Investments bought 75,822 Annovis Bio shares in Q1 2026, an estimated $208K.
  • Annovis Bio made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #3016 holding.
  • Two Sigma Investments first reported a position in Annovis Bio in Q3 2021 and has held it in 6 quarters since.
  • Two Sigma Investments's Annovis Bio position peaked at $3.1M in Q3 2021.
  • 56 funds tracked by Wall St. Rank held Annovis Bio as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.