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Alto Neuroscience
ANRO

110 hedge funds and large institutions have $602M invested in Alto Neuroscience in 2026 Q1 according to their latest regulatory filings, with 25 funds opening new positions, 27 increasing their positions, 43 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

2,756% more call options, than puts

Call options by funds: $10.4M | Put options by funds: $364K

150% more first-time investments, than exits

New positions opened: 25 | Existing positions closed: 10

38% more capital invested

Capital invested by funds: $436M → $602M (+$167M)

13% more funds holding

Funds holding: 97 → 110 (+13)

5.17% more ownership

Funds ownership: 78.82% → 83.99% (+5.2%)

0% more funds holding in top 10

Funds holding in top 10: 3 → 3 (0)

37% less repeat investments, than reductions

Existing positions increased: 27 | Existing positions reduced: 43

Holders
110
Holders Change
+13
Holders Change %
+13.4%
% of All Funds
1.35%
Holding in Top 10
3
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.04%
New
25
Increased
27
Reduced
43
Closed
10
Calls
$10.4M
Puts
$364K
Net Calls
+$10M
Net Calls Change
+$1.99M

Top Buyers

Rank Fund Capital Flow
1
SSC
Spruce Street Capital
New York
+$20.4M
2
CC
Commodore Capital
New York
+$16.7M
3
AAA
Affinity Asset Advisors
New York
+$9.27M
4
VA
VR Adviser
New York
+$9.27M
5
Jennison Associates
Jennison Associates
New York
+$7.16M

Top Sellers

Rank Fund Capital Flow
1
Point72 Asset Management
Point72 Asset Management
Connecticut
-$20.5M
2
AC
Armistice Capital
New York
-$11.6M
3
VPC
Vestal Point Capital
New York
-$7.8M
4
Alkeon Capital Management
Alkeon Capital Management
New York
-$4.63M
5
PLC
Peapod Lane Capital
New York
-$4.52M
Name Holding Trade Value Shares
Change 		Change in
Stake
Two Sigma Investments
26
Two Sigma Investments
New York
$4.86M +$1.4M +75,782 +54%
Qube Research & Technologies (QRT)
27
Qube Research & Technologies (QRT)
United Kingdom
$4.7M +$1.79M +96,476 +86%
State Street
28
State Street
Massachusetts
$4.48M +$1.28M +68,838 +53%
Marshall Wace
29
Marshall Wace
United Kingdom
$3.96M -$311K -16,762 -9%
AIC
30
AWM Investment Company
New York
$3.82M -$1.02M -55,000 -24%
O
31
OrbiMed
New York
$3.77M +$788K +42,500 +34%
VFT
32
Vanguard Fiduciary Trust
Pennsylvania
$3.72M +$3.06M +165,272 New
BFM
33
Boothbay Fund Management
New York
$3.13M – – –
EP
34
Eversept Partners
New York
$2.81M +$2.32M +125,168 New
Goldman Sachs
35
Goldman Sachs
New York
$2.35M -$956K -51,602 -33%
Renaissance Technologies
36
Renaissance Technologies
New York
$2.33M +$113K +6,100 +6%
SVCM
37
Saturn V Capital Management
Texas
$2M +$1.65M +88,999 New
Stifel Financial
38
Stifel Financial
Missouri
$1.94M -$15.4K -829 -1%
AC
39
Almitas Capital
California
$1.77M – – –
Morgan Stanley
40
Morgan Stanley
New York
$1.54M +$57K +3,073 +5%
Acadian Asset Management
41
Acadian Asset Management
Massachusetts
$1.35M +$46.9K +2,530 +4%
Wellington Management Group
42
Wellington Management Group
Massachusetts
$1.34M -$171K -9,217 -13%
BCM
43
Bridgeway Capital Management
Texas
$1.18M -$463K -25,000 -32%
D.E. Shaw & Co
44
D.E. Shaw & Co
New York
$1.02M -$1.47M -79,452 -64%
TD Asset Management
45
TD Asset Management
Ontario, Canada
$985K +$812K +43,800 New
Hudson Bay Capital Management
46
Hudson Bay Capital Management
Connecticut
$984K +$166K +8,973 +26%
AI
47
AdvisorShares Investments
Maryland
$922K -$56.6K -3,054 -7%
6CM
48
683 Capital Management
New York
$899K -$459K -24,782 -38%
XT
49
XTX Topco
Cayman Islands
$896K +$352K +19,017 +91%
Dimensional Fund Advisors
50
Dimensional Fund Advisors
Texas
$884K +$151K +8,148 +26%
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ANRO Hedge Fund Activity: Q1 2026 in Review

110 of the 8,126 institutional investors tracked by Wall St. Rank reported a position in Alto Neuroscience (ANRO) for Q1 2026, worth a combined $602M — up 38% from $436M a quarter earlier.

Buyers outnumbered sellers: 25 funds opened new ANRO positions and 10 closed out — a net gain of 15 holders — while 27 added to existing stakes and 43 trimmed.

The largest buyer was Spruce Street Capital, adding an estimated $20.4M. The largest seller was Point72 Asset Management, cutting an estimated $20.5M.

  • 110 institutional investors held Alto Neuroscience (ANRO) as of Q1 2026, up from 97 in Q4 2025.
  • Funds reported $602M of Alto Neuroscience stock for Q1 2026, up 38% quarter-over-quarter.
  • 25 funds opened new Alto Neuroscience positions in Q1 2026 and 10 closed out, a net change of +15 holders.
  • The largest Alto Neuroscience buyer in Q1 2026 was Spruce Street Capital, an estimated $20.4M added.
  • The largest Alto Neuroscience seller in Q1 2026 was Point72 Asset Management, an estimated $20.5M sold.

Based on aggregated 13F filings for Q1 2026.