Two Sigma Investments
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Two Sigma Investments’s Alto Neuroscience ANRO Stock Holding History

Two Sigma Investments’s Portfolio ANRO Stock Details ANRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$4.86M Buy
216,099
+75,782
+54% +$1.4M ﹤0.01% 2000
2025
Q4 		$2.5M Buy
140,317
+23,738
+20% +$299K ﹤0.01% 2285
2025
Q3 		$469K Buy
116,579
+71,844
+161% +$238K ﹤0.01% 3013
2025
Q2 		$98.4K Buy
44,735
+18,593
+71% +$44.2K ﹤0.01% 3001
2025
Q1 		$56.5K Sell
26,142
-4,558
-15% -$16.3K ﹤0.01% 3033
2024
Q4 		$130K Buy
30,700
+17,760
+137% +$111K ﹤0.01% 2937
2024
Q3 		$148K Buy
+12,940
New +$158K ﹤0.01% 2847

Other funds holding ANRO

AWG
Alpha Wave Global New York $791M AUM 113.77% 1-Year Est. Return
CC
Commodore Capital New York $1.73B AUM 298.96% 1-Year Est. Return
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
PA
Perceptive Advisors New York $5.12B AUM 314.02% 1-Year Est. Return
SSC
Spruce Street Capital New York $416M AUM
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
Franklin Resources
Franklin Resources San Mateo, California $408B AUM 30.18% 1-Year Est. Return
VC
Vivo Capital Palo Alto, California $1.2B AUM 911.44% 1-Year Est. Return
AC
Armistice Capital New York $5.62B AUM 36.06% 1-Year Est. Return
Millennium Management
Millennium Management New York $240B AUM 35.51% 1-Year Est. Return

Two Sigma Investments's ANRO Position: Q1 2026 in Review

Two Sigma Investments increased its Alto Neuroscience (ANRO) stake by 54% in Q1 2026, buying an estimated $1.4M and bringing the position to 216,099 shares worth $4.86M. The position accounts for ﹤0.01% of the portfolio, ranked #2000.

Two Sigma Investments first reported a position in ANRO in Q3 2024 and has held it in 7 quarters since. 110 funds tracked by Wall St. Rank hold ANRO as of Q1 2026.

  • Two Sigma Investments held 216,099 shares of Alto Neuroscience worth $4.86M as of Q1 2026.
  • Two Sigma Investments bought 75,782 Alto Neuroscience shares in Q1 2026, an estimated $1.4M.
  • Alto Neuroscience made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #2000 holding.
  • Two Sigma Investments first reported a position in Alto Neuroscience in Q3 2024 and has held it in 7 quarters since.
  • 110 funds tracked by Wall St. Rank held Alto Neuroscience as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.