Two Sigma Investments
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Two Sigma Investments’s Alto Neuroscience ANRO Stock Holding History

Two Sigma Investments’s Portfolio ANRO Stock Details ANRO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q2 		$3.89M Sell
147,299
-68,800
-32% -$1.59M ﹤0.01% 2386
2026
Q1 		$4.86M Buy
216,099
+75,782
+54% +$1.4M ﹤0.01% 2000
2025
Q4 		$2.5M Buy
140,317
+23,738
+20% +$299K ﹤0.01% 2285
2025
Q3 		$469K Buy
116,579
+71,844
+161% +$238K ﹤0.01% 3013
2025
Q2 		$98.4K Buy
44,735
+18,593
+71% +$44.2K ﹤0.01% 3001
2025
Q1 		$56.5K Sell
26,142
-4,558
-15% -$16.3K ﹤0.01% 3033
2024
Q4 		$130K Buy
30,700
+17,760
+137% +$111K ﹤0.01% 2937
2024
Q3 		$148K Buy
+12,940
New +$158K ﹤0.01% 2847

Other funds holding ANRO

AWG
Alpha Wave Global New York $6.24B AUM 59.73% 1-Year Est. Return
CC
Commodore Capital New York $1.68B AUM 375.52% 1-Year Est. Return
BlackRock
BlackRock New York $6.73T AUM 46.02% 1-Year Est. Return
PA
Perceptive Advisors New York $6.66B AUM 360.84% 1-Year Est. Return
Adage Capital Partners
Adage Capital Partners Boston, Massachusetts $71.3B AUM 56.8% 1-Year Est. Return
Vanguard Capital Management
Vanguard Capital Management Malvern, Pennsylvania $4.68T AUM
SSC
Spruce Street Capital New York $510M AUM
VC
Vivo Capital Palo Alto, California $1.1B AUM 799.93% 1-Year Est. Return
Franklin Resources
Franklin Resources San Mateo, California $462B AUM 39.16% 1-Year Est. Return
AC
Armistice Capital New York $8.17B AUM 68.82% 1-Year Est. Return

Two Sigma Investments's ANRO Position: Q2 2026 in Review

Two Sigma Investments reduced its Alto Neuroscience (ANRO) stake by 32% in Q2 2026, selling an estimated $1.59M and leaving 147,299 shares worth $3.89M. The position accounts for ﹤0.01% of the portfolio, ranked #2386.

Two Sigma Investments first reported a position in ANRO in Q3 2024 and has held it in 8 quarters since. The position peaked at $4.86M in Q1 2026. 114 funds tracked by Wall St. Rank hold ANRO as of Q2 2026.

  • Two Sigma Investments held 147,299 shares of Alto Neuroscience worth $3.89M as of Q2 2026.
  • Two Sigma Investments sold 68,800 Alto Neuroscience shares in Q2 2026, an estimated $1.59M.
  • Alto Neuroscience made up ﹤0.01% of Two Sigma Investments's portfolio in Q2 2026, its #2386 holding.
  • Two Sigma Investments first reported a position in Alto Neuroscience in Q3 2024 and has held it in 8 quarters since.
  • Two Sigma Investments's Alto Neuroscience position peaked at $4.86M in Q1 2026.
  • 114 funds tracked by Wall St. Rank held Alto Neuroscience as of Q2 2026.

Based on Two Sigma Investments's 13F filing for Q2 2026, filed 14 Aug 2026.