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Alto Neuroscience
ANRO

97 hedge funds and large institutions have $436M invested in Alto Neuroscience in 2025 Q4 according to their latest regulatory filings, with 30 funds opening new positions, 27 increasing their positions, 25 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

38,295% more call options, than puts

Call options by funds: $8.06M | Put options by funds: $21K

547% more capital invested

Capital invested by funds: $67.4M → $436M (+$368M)

233% more first-time investments, than exits

New positions opened: 30 | Existing positions closed: 9

50% more funds holding in top 10

Funds holding in top 10: 2 → 3 (+1)

26% more funds holding

Funds holding: 77 → 97 (+20)

16.93% more ownership

Funds ownership: 61.89% → 78.82% (+17%)

8% more repeat investments, than reductions

Existing positions increased: 27 | Existing positions reduced: 25

Holders
97
Holders Change
+20
Holders Change %
+25.97%
% of All Funds
1.18%
Holding in Top 10
3
Holding in Top 10 Change
+1
Holding in Top 10 Change %
+50%
% of All Funds
0.04%
New
30
Increased
27
Reduced
25
Closed
9
Calls
$8.06M
Puts
$21K
Net Calls
+$8.04M
Net Calls Change
+$8.04M

Top Buyers

Rank Fund Capital Flow
1
CC
Commodore Capital
New York
+$23M
2
PA
Perceptive Advisors
New York
+$20.5M
3
VPC
Vestal Point Capital
New York
+$19.3M
4
VC
Vivo Capital
California
+$13M
5
IC
Ikarian Capital
Texas
+$5.1M

Top Sellers

Rank Fund Capital Flow
1
Marshall Wace
Marshall Wace
United Kingdom
-$7.96M
2
O
OrbiMed
New York
-$1.57M
3
UBS Group
UBS Group
Switzerland
-$1.52M
4
AC
Almitas Capital
California
-$1.47M
5
AC
Armistice Capital
New York
-$1.26M
Name Holding Trade Value Shares
Change 		Change in
Stake
Two Sigma Investments
26
Two Sigma Investments
New York
$2.5M +$299K +23,738 +20%
BFM
27
Boothbay Fund Management
New York
$2.48M +$1.35M +106,832 +329%
State Street
28
State Street
Massachusetts
$2.33M +$346K +27,480 +27%
O
29
OrbiMed
New York
$2.23M -$1.57M -125,000 -50%
D.E. Shaw & Co
30
D.E. Shaw & Co
New York
$2.22M +$1.57M +124,795 New
Susquehanna International Group
31
Susquehanna International Group
Pennsylvania
$2.1M -$472K -37,520 -24%
Qube Research & Technologies (QRT)
32
Qube Research & Technologies (QRT)
United Kingdom
$2.01M +$1.42M +112,792 New
Renaissance Technologies
33
Renaissance Technologies
New York
$1.73M +$272K +21,627 +29%
Stifel Financial
34
Stifel Financial
Missouri
$1.55M -$439K -34,836 -29%
AC
35
Almitas Capital
California
$1.4M -$1.47M -116,625 -60%
BCM
36
Bridgeway Capital Management
Texas
$1.38M – – –
IC
37
IEQ Capital
California
$1.34M +$155K +12,315 +20%
Wellington Management Group
38
Wellington Management Group
Massachusetts
$1.23M +$869K +69,016 New
Morgan Stanley
39
Morgan Stanley
New York
$1.17M +$57.2K +4,545 +7%
6CM
40
683 Capital Management
New York
$1.15M +$816K +64,782 New
Acadian Asset Management
41
Acadian Asset Management
Massachusetts
$1.02M +$542K +43,023 +296%
AI
42
AdvisorShares Investments
Maryland
$785K +$555K +44,077 New
Allianz Asset Management
43
Allianz Asset Management
Germany
$765K +$75.6K +6,000 +16%
QCM
44
Quantinno Capital Management
New York
$633K – – –
Hudson Bay Capital Management
45
Hudson Bay Capital Management
Connecticut
$619K +$438K +34,789 New
SCM
46
SCS Capital Management
Massachusetts
$594K -$420K -33,388 -50%
BNP Paribas Financial Markets
47
BNP Paribas Financial Markets
France
$592K +$412K +32,721 +6,366%
Dimensional Fund Advisors
48
Dimensional Fund Advisors
Texas
$555K +$393K +31,176 New
Barclays
49
Barclays
United Kingdom
$541K +$382K +30,350 +72,262%
T. Rowe Price Associates
50
T. Rowe Price Associates
Maryland
$539K -$368K -29,200 -49%
1
2
3 4 5

ANRO Hedge Fund Activity: Q4 2025 in Review

97 of the 8,224 institutional investors tracked by Wall St. Rank reported a position in Alto Neuroscience (ANRO) for Q4 2025, worth a combined $436M — up 547% from $67.4M a quarter earlier.

Buyers outnumbered sellers: 30 funds opened new ANRO positions and 9 closed out — a net gain of 21 holders — while 27 added to existing stakes and 25 trimmed.

The largest buyer was Commodore Capital, opening a new position worth an estimated $23M. The largest seller was Marshall Wace, cutting an estimated $7.96M.

  • 97 institutional investors held Alto Neuroscience (ANRO) as of Q4 2025, up from 77 in Q3 2025.
  • Funds reported $436M of Alto Neuroscience stock for Q4 2025, up 547% quarter-over-quarter.
  • 30 funds opened new Alto Neuroscience positions in Q4 2025 and 9 closed out, a net change of +21 holders.
  • The largest Alto Neuroscience buyer in Q4 2025 was Commodore Capital, an estimated $23M added.
  • The largest Alto Neuroscience seller in Q4 2025 was Marshall Wace, an estimated $7.96M sold.

Based on aggregated 13F filings for Q4 2025.