Amgen
AMGN
3,084 hedge funds and large institutions have $147B invested in Amgen in 2025 Q4 according to their latest regulatory filings, with 417 funds opening new positions, 1,181 increasing their positions, 1,106 reducing their positions, and 94 closing their positions.
344% more first-time investments, than exits
New positions opened: 417 | Existing positions closed: 94
76% more funds holding in top 10
Funds holding in top 10: 29 → 51 (+22)
23% more capital invested
Capital invested by funds: $119B → $147B (+$27.6B)
12% more call options, than puts
Call options by funds: $2.14B | Put options by funds: $1.92B
9% more funds holding
Funds holding: 2,819 → 3,084 (+265)
4.84% more ownership
Funds ownership: 78.59% → 83.42% (+4.8%)
7% more repeat investments, than reductions
Existing positions increased: 1,181 | Existing positions reduced: 1,106
Top Buyers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
Invesco
Atlanta,
Georgia
|
+$3.94B |
| 2 |
Capital World Investors
Los Angeles,
California
|
+$1.36B |
| 3 |
BlackRock
New York
|
+$432M |
| 4 |
State Street
Boston,
Massachusetts
|
+$408M |
| 5 |
Geode Capital Management
Boston,
Massachusetts
|
+$329M |
Top Sellers
| Rank | Fund | Capital Flow |
|---|---|---|
| 1 |
JP Morgan Chase
New York
|
-$614M |
| 2 |
Charles Schwab
San Francisco,
California
|
-$552M |
| 3 |
Capital International Investors
Los Angeles,
California
|
-$319M |
| 4 |
Primecap Management
Pasadena,
California
|
-$255M |
| 5 |
Barclays
London,
United Kingdom
|
-$246M |
AMGN Hedge Fund Activity: Q4 2025 in Review
3,084 of the 8,225 institutional investors tracked by Wall St. Rank reported a position in Amgen (AMGN) for Q4 2025, worth a combined $147B — up 23% from $119B a quarter earlier.
Buyers outnumbered sellers: 417 funds opened new AMGN positions and 94 closed out — a net gain of 323 holders — while 1,181 added to existing stakes and 1,106 trimmed.
The largest buyer was Invesco, adding an estimated $3.94B. The largest seller was JP Morgan Chase, cutting an estimated $614M.
- 3,084 institutional investors held Amgen (AMGN) as of Q4 2025, up from 2,819 in Q3 2025.
- Funds reported $147B of Amgen stock for Q4 2025, up 23% quarter-over-quarter.
- 417 funds opened new Amgen positions in Q4 2025 and 94 closed out, a net change of +323 holders.
- The largest Amgen buyer in Q4 2025 was Invesco, an estimated $3.94B added.
- The largest Amgen seller in Q4 2025 was JP Morgan Chase, an estimated $614M sold.
Based on aggregated 13F filings for Q4 2025.