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ALX Oncology
ALXO

57 hedge funds and large institutions have $33.5M invested in ALX Oncology in 2025 Q4 according to their latest regulatory filings, with 8 funds opening new positions, 18 increasing their positions, 15 reducing their positions, and 10 closing their positions.

New
Increased
Maintained
Reduced
Closed

150% more call options, than puts

Call options by funds: $240K | Put options by funds: $96K

20% more repeat investments, than reductions

Existing positions increased: 18 | Existing positions reduced: 15

1.98% more ownership

Funds ownership: 51.89% → 53.87% (+2%)

0% more funds holding in top 10

Funds holding in top 10: 1 → 1 (0)

7% less funds holding

Funds holding: 61 → 57 (-4)

20% less first-time investments, than exits

New positions opened: 8 | Existing positions closed: 10

35% less capital invested

Capital invested by funds: $51.3M → $33.5M (-$17.8M)

Holders
57
Holders Change
-4
Holders Change %
-6.56%
% of All Funds
0.69%
Holding in Top 10
1
Holding in Top 10 Change
–
Holding in Top 10 Change %
–
% of All Funds
0.01%
New
8
Increased
18
Reduced
15
Closed
10
Calls
$240K
Puts
$96K
Net Calls
+$144K
Net Calls Change
-$279K

Top Buyers

Rank Fund Capital Flow
1
UBS Group
UBS Group
Switzerland
+$1.05M
2
DCM
Driehaus Capital Management
Illinois
+$950K
3
Millennium Management
Millennium Management
New York
+$881K
4
Renaissance Technologies
Renaissance Technologies
New York
+$392K
5
Acadian Asset Management
Acadian Asset Management
Massachusetts
+$232K

Top Sellers

Rank Fund Capital Flow
1
Ameriprise
Ameriprise
Minnesota
-$1.19M
2
PFM
Privium Fund Management
Netherlands
-$932K
3
RG
Redmile Group
California
-$103K
4
JP Morgan Chase
JP Morgan Chase
New York
-$93.6K
5
XT
XTX Topco
Cayman Islands
-$48.7K
Name Holding Trade Value Shares
Change 		Change in
Stake
Group One Trading
51
Group One Trading
Illinois
$585 +$784 +518 New
BNP Paribas Financial Markets
52
BNP Paribas Financial Markets
France
$542 – – –
SS
53
SBI Securities
Japan
$466 -$15 -10 -2%
PNC Financial Services Group
54
PNC Financial Services Group
Pennsylvania
$113 – – –
JP Morgan Chase
55
JP Morgan Chase
New York
$112 -$93.6K -61,800 -100%
Optiver Holding
56
Optiver Holding
Netherlands
$31 -$2 -1 -4%
Ameriprise
57
Ameriprise
Minnesota
– -$1.19M -652,897 Closed
PFM
58
Privium Fund Management
Netherlands
– -$932K -509,059 Closed
XT
59
XTX Topco
Cayman Islands
– -$48.7K -26,621 Closed
HF
60
HRT Financial
New York
– -$41K -22,535 Closed
Qube Research & Technologies (QRT)
61
Qube Research & Technologies (QRT)
United Kingdom
– -$31K -16,946 Closed
AQR Capital Management
62
AQR Capital Management
Connecticut
– -$19.8K -10,793 Closed
Federated Hermes
63
Federated Hermes
Pennsylvania
– -$4.34K -2,374 Closed
Citigroup
64
Citigroup
New York
– -$4.17K -2,278 Closed
EWA
65
EverSource Wealth Advisors
Alabama
– -$913 -499 Closed
Carson Wealth (CWM LLC)
66
Carson Wealth (CWM LLC)
Nebraska
– -$73 -48 -33%
AAP
67
Arax Advisory Partners
Colorado
– -$3 -2 Closed
1 2
3

ALXO Hedge Fund Activity: Q4 2025 in Review

57 of the 8,228 institutional investors tracked by Wall St. Rank reported a position in ALX Oncology (ALXO) for Q4 2025, worth a combined $33.5M — down 35% from $51.3M a quarter earlier.

Sellers outnumbered buyers: 10 funds closed out of ALXO and 8 opened new positions — a net loss of 2 holders — while 15 trimmed existing stakes and 18 added.

The largest buyer was UBS Group, adding an estimated $1.05M. The largest seller was Ameriprise, exiting entirely with an estimated $1.19M sold.

  • 57 institutional investors held ALX Oncology (ALXO) as of Q4 2025, down from 61 in Q3 2025.
  • Funds reported $33.5M of ALX Oncology stock for Q4 2025, down 35% quarter-over-quarter.
  • 8 funds opened new ALX Oncology positions in Q4 2025 and 10 closed out, a net change of -2 holders.
  • The largest ALX Oncology buyer in Q4 2025 was UBS Group, an estimated $1.05M added.
  • The largest ALX Oncology seller in Q4 2025 was Ameriprise, an estimated $1.19M sold.

Based on aggregated 13F filings for Q4 2025.