|
1
|
Decheng Capital
Menlo Park,
California
|
–
|
-$330M
|
-8,317,924
|
Closed
|
|
|
2
|
Avoro Capital Advisors
New York
|
–
|
-$229M
|
-5,775,000
|
Closed
|
|
|
3
|
|
–
|
-$142M
|
-3,575,092
|
Closed
|
|
|
4
|
Frazier Life Sciences Management
Palo Alto,
California
|
–
|
-$124M
|
-3,131,008
|
Closed
|
|
|
5
|
T. Rowe Price Associates
Baltimore,
Maryland
|
–
|
-$122M
|
-3,080,220
|
Closed
|
|
|
6
|
State Street
Boston,
Massachusetts
|
–
|
-$113M
|
-2,845,839
|
Closed
|
|
|
7
|
Vanguard Group
Malvern,
Pennsylvania
|
–
|
-$108M
|
-2,712,285
|
Closed
|
|
|
8
|
Cormorant Asset Management
Boston,
Massachusetts
|
–
|
-$107M
|
-2,700,000
|
Closed
|
|
|
9
|
|
–
|
-$106M
|
-2,680,496
|
Closed
|
|
|
10
|
Lynx1 Capital Management
San Juan,
Puerto Rico
|
–
|
-$89.3M
|
-2,253,183
|
Closed
|
|
|
11
|
Paradigm Biocapital Advisors
New York
|
–
|
-$84.1M
|
-2,121,163
|
Closed
|
|
|
12
|
Darwin Global Management
St. Helier,
Jersey
|
–
|
-$78.6M
|
-1,982,016
|
Closed
|
|
|
13
|
Commodore Capital
New York
|
–
|
-$54.5M
|
-1,375,000
|
Closed
|
|
|
14
|
Octagon Capital Advisors
New York
|
–
|
-$49.2M
|
-1,241,300
|
Closed
|
|
|
15
|
Avidity Partners Management
Dallas,
Texas
|
–
|
-$46.6M
|
-1,174,700
|
Closed
|
|
|
16
|
Great Point Partners
Greenwich,
Connecticut
|
–
|
-$44.7M
|
-1,128,499
|
Closed
|
|
|
17
|
Franklin Resources
San Mateo,
California
|
–
|
-$43.3M
|
-1,093,203
|
Closed
|
|
|
18
|
Geode Capital Management
Boston,
Massachusetts
|
–
|
-$36.1M
|
-910,599
|
Closed
|
|
|
19
|
|
–
|
-$31.3M
|
-789,645
|
Closed
|
|
|
20
|
Two Sigma Advisers
New York
|
–
|
-$26.5M
|
-668,775
|
Closed
|
|
|
21
|
Vivo Capital
Palo Alto,
California
|
–
|
-$20.8M
|
-520,505
|
Closed
|
|
|
22
|
Two Sigma Investments
New York
|
–
|
-$20.6M
|
-519,971
|
Closed
|
|
|
23
|
Nuveen
Charlotte,
North Carolina
|
–
|
-$20.3M
|
-513,175
|
Closed
|
|
|
24
|
First Light Asset Management
Edina,
Minnesota
|
–
|
-$19.9M
|
-501,243
|
Closed
|
|
|
25
|
Janus Henderson Group
London,
|
–
|
-$17.8M
|
-450,827
|
Closed
|
|
