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Agios Pharmaceuticals
AGIO

220 hedge funds and large institutions have $2.55B invested in Agios Pharmaceuticals in 2025 Q3 according to their latest regulatory filings, with 43 funds opening new positions, 68 increasing their positions, 69 reducing their positions, and 35 closing their positions.

New
Increased
Maintained
Reduced
Closed

100% more funds holding in top 10

Funds holding in top 10: 2 → 4 (+2)

24% more capital invested

Capital invested by funds: $2.05B → $2.55B (+$494M)

23% more first-time investments, than exits

New positions opened: 43 | Existing positions closed: 35

3% more funds holding

Funds holding: 214 → 220 (+6)

2.77% more ownership

Funds ownership: 106.52% → 109.29% (+2.8%)

9% more call options, than puts

Call options by funds: $85.2M | Put options by funds: $78.2M

1% less repeat investments, than reductions

Existing positions increased: 68 | Existing positions reduced: 69

Holders
220
Holders Change
+6
Holders Change %
+2.8%
% of All Funds
2.89%
Holding in Top 10
4
Holding in Top 10 Change
+2
Holding in Top 10 Change %
+100%
% of All Funds
0.05%
New
43
Increased
68
Reduced
69
Closed
35
Calls
$85.2M
Puts
$78.2M
Net Calls
+$7.06M
Net Calls Change
+$4.49M

Top Buyers

1
Wellington Management Group
Wellington Management Group
Massachusetts
+$77.1M
2
PBA
Paradigm Biocapital Advisors
New York
+$57.6M
3
TCM
TCG Crossover Management
California
+$27.6M
4
Balyasny Asset Management
Balyasny Asset Management
Illinois
+$18.6M
5
EAM
Erste Asset Management
Austria
+$16.5M

Top Sellers

1
JP Morgan Chase
JP Morgan Chase
New York
-$31.8M
2
T. Rowe Price Associates
T. Rowe Price Associates
Maryland
-$23.2M
3
Citadel Advisors
Citadel Advisors
Florida
-$22.2M
4
O
OrbiMed
New York
-$18.6M
5
Marshall Wace
Marshall Wace
United Kingdom
-$17.2M
Name Holding Trade Value Shares
Change 		Change in
Stake
ACH
26
ArrowMark Colorado Holdings
Colorado
$27.3M +$799K +21,231 +3%
SCM
27
SCS Capital Management
Massachusetts
$24M -$200K -5,320 -0.9%
Northern Trust
28
Northern Trust
Illinois
$22.3M -$52.5K -1,395 -0.3%
Connor, Clark & Lunn Investment Management (CC&L)
29
Connor, Clark & Lunn Investment Management (CC&L)
British Columbia, Canada
$21.3M +$936K +24,873 +5%
Balyasny Asset Management
30
Balyasny Asset Management
Illinois
$19.9M +$18.6M +495,491 New
BFM
31
Boothbay Fund Management
New York
$19.9M +$1.82M +48,322 +11%
Citadel Advisors
32
Citadel Advisors
Florida
$19.7M -$22.2M -589,488 -55%
Charles Schwab
33
Charles Schwab
California
$19.4M +$231K +6,145 +1%
Morgan Stanley
34
Morgan Stanley
New York
$16.7M +$4.7M +125,033 +43%
Artisan Partners
35
Artisan Partners
Wisconsin
$16.2M +$487K +12,959 +3%
Jane Street
36
Jane Street
New York
$15.9M +$13.6M +361,631 +1,080%
D.E. Shaw & Co
37
D.E. Shaw & Co
New York
$14.8M -$8.59M -228,453 -38%
Legal & General Group
38
Legal & General Group
United Kingdom
$13M +$9.73M +258,629 +402%
Bank of New York Mellon
39
Bank of New York Mellon
New York
$10.8M +$129K +3,442 +1%
Pictet Asset Management
40
Pictet Asset Management
Switzerland
$10.7M -$849K -22,579 -8%
PAI
41
Palo Alto Investors
California
$10.7M -$124K -3,286 -1%
SC
42
SummitTX Capital
Texas
$10.6M +$9.89M +262,977 New
EHI
43
Eagle Health Investments
Connecticut
$9.88M -$3.18M -84,600 -26%
UBS Group
44
UBS Group
Switzerland
$9.75M +$4.66M +123,979 +104%
Marshall Wace
45
Marshall Wace
United Kingdom
$9.1M -$17.2M -457,845 -67%
Barclays
46
Barclays
United Kingdom
$8.67M +$1.33M +35,336 +20%
HS
47
HighVista Strategies
Massachusetts
$7.84M +$4.71M +125,171 +178%
BBA
48
Baker Bros. Advisors
New York
$7.62M – – –
JP Morgan Chase
49
JP Morgan Chase
New York
$7.35M -$31.8M -844,317 -82%
AIM
50
AXA Investment Managers
France
$7.13M +$6.68M +177,675 New
1
2
3 4 5

AGIO Hedge Fund Activity: Q3 2025 in Review

220 of the 7,619 institutional investors tracked by Wall St. Rank reported a position in Agios Pharmaceuticals (AGIO) for Q3 2025, worth a combined $2.55B — up 24% from $2.05B a quarter earlier.

Buyers outnumbered sellers: 43 funds opened new AGIO positions and 35 closed out — a net gain of 8 holders — while 68 added to existing stakes and 69 trimmed.

The largest buyer was Wellington Management Group, adding an estimated $77.1M. The largest seller was JP Morgan Chase, cutting an estimated $31.8M.

  • 220 institutional investors held Agios Pharmaceuticals (AGIO) as of Q3 2025, up from 214 in Q2 2025.
  • Funds reported $2.55B of Agios Pharmaceuticals stock for Q3 2025, up 24% quarter-over-quarter.
  • 43 funds opened new Agios Pharmaceuticals positions in Q3 2025 and 35 closed out, a net change of +8 holders.
  • The largest Agios Pharmaceuticals buyer in Q3 2025 was Wellington Management Group, an estimated $77.1M added.
  • The largest Agios Pharmaceuticals seller in Q3 2025 was JP Morgan Chase, an estimated $31.8M sold.

Based on aggregated 13F filings for Q3 2025.