Baker Bros. Advisors’s Agios Pharmaceuticals AGIO Stock Holding History

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2025 Q4	–	Sell	-189,866	Closed	-$7.62M	–	88
2025 Q3	$7.62M	Hold	189,866	–	–	0.06%	66
2025 Q2	$6.31M	Buy	+189,866	New	+$5.75M	0.06%	61
2018 Q1	–	Sell	-128,666	Closed	-$7.36M	–	115
2017 Q4	$7.36M	Hold	128,666	–	–	0.06%	66
2017 Q3	$8.59M	Hold	128,666	–	–	0.07%	56
2017 Q2	$6.62M	Hold	128,666	–	–	0.06%	58
2017 Q1	$7.51M	Hold	128,666	–	–	0.06%	56
2016 Q4	$5.37M	Sell	128,666 -79,249	-38%	-$4.16M	0.05%	60
2016 Q3	$11M	Hold	207,915	–	–	0.1%	52
2016 Q2	$8.71M	Sell	207,915 -100,000	-32%	-$4.94M	0.09%	59
2016 Q1	$12.5M	Buy	307,915 +207,915	+208%	+$8.89M	0.13%	49
2015 Q4	$6.49M	Hold	100,000	–	–	0.05%	70
2015 Q3	$7.06M	Hold	100,000	–	–	0.07%	69
2015 Q2	$11.1M	Sell	100,000 -49,954	-33%	-$5.38M	0.1%	61
2015 Q1	$14.1M	Sell	149,954 -13,439	-8%	-$1.51M	0.12%	52
2014 Q4	$18.3M	Sell	163,393 -6,500	-4%	-$580K	0.19%	39
2014 Q3	$10.4M	Sell	169,893 -30,000	-15%	-$1.29M	0.13%	42
2014 Q2	$9.16M	Hold	199,893	–	–	0.11%	47
2014 Q1	$7.83M	Sell	199,893 -5,857	-3%	-$196K	0.1%	55
2013 Q4	$4.93M	Buy	205,750 +5,750	+3%	+$131K	0.07%	65
2013 Q3	$5.59M	Buy	+200,000	New	+$5.52M	0.08%	54