Two Sigma Investments
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Two Sigma Investments’s Talphera TLPH Stock Holding History

Two Sigma Investments’s Portfolio TLPH Stock Details TLPH Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-24,588
Closed -$28K – 4924
2025
Q4 		$28K Buy
+24,588
New +$29.6K ﹤0.01% 3975
2022
Q4 		– Sell
-3,267
Closed -$14K – 3086
2022
Q3 		$14K Buy
+3,267
New +$17.1K ﹤0.01% 2399
2021
Q2 		– Sell
-2,309
Closed -$79K – 4555
2021
Q1 		$79K Buy
+2,309
New +$91.6K ﹤0.01% 3718
2020
Q3 		– Sell
-5,329
Closed -$129K – 3554
2020
Q2 		$129K Buy
+5,329
New +$148K ﹤0.01% 2753
2020
Q1 		– Sell
-1,264
Closed -$53K – 3818
2019
Q4 		$53K Buy
+1,264
New +$51.6K ﹤0.01% 3567
2019
Q2 		– Sell
-3,557
Closed -$248K – 3669
2019
Q1 		$248K Sell
3,557
-24,413
-87% -$1.42M ﹤0.01% 2723
2018
Q4 		$1.29M Buy
27,970
+24,933
+821% +$1.67M 0.01% 1483
2018
Q3 		$234K Buy
+3,037
New +$195K ﹤0.01% 2917
2016
Q2 		– Sell
-547
Closed -$34K – 3234
2016
Q1 		$34K Sell
547
-1,580
-74% -$110K ﹤0.01% 2732
2015
Q4 		$164K Buy
+2,127
New +$182K ﹤0.01% 2505
2014
Q2 		– Sell
-2,499
Closed -$600K – 2349
2014
Q1 		$600K Buy
+2,499
New +$592K ﹤0.01% 1409

Other funds holding TLPH

ACM
AIGH Capital Management Baltimore, Maryland $733M AUM 327.32% 1-Year Est. Return
RSCM
Rock Springs Capital Management Baltimore, Maryland $1.7B AUM 93.03% 1-Year Est. Return
NCM
Nantahala Capital Management New Canaan, Connecticut $2.72B AUM 121.58% 1-Year Est. Return
RA
Rosalind Advisors Toronto, Ontario, Canada $249M AUM 80.12% 1-Year Est. Return
BL
Bleichroeder LP New York $579M AUM 94.36% 1-Year Est. Return
CF
Cantor Fitzgerald New York $6.78B AUM 29.01% 1-Year Est. Return
EAM
Empery Asset Management New York $83M AUM
CM
Caption Management Oklahoma City, Oklahoma $17.1B AUM 70.99% 1-Year Est. Return
AC
Almitas Capital Santa Monica, California $443M AUM 42.36% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM

Two Sigma Investments's TLPH Position: Q1 2026 in Review

Two Sigma Investments sold out of Talphera (TLPH) in Q1 2026, closing a stake of 24,588 shares — an estimated $28K sold.

Two Sigma Investments first reported a position in TLPH in Q1 2014 and held it in 11 quarters. The position peaked at $1.29M in Q4 2018. 45 funds tracked by Wall St. Rank hold TLPH as of Q1 2026.

  • Two Sigma Investments reported no remaining Talphera position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Investments sold 24,588 Talphera shares in Q1 2026, an estimated $28K.
  • Two Sigma Investments first reported a position in Talphera in Q1 2014 and held it in 11 quarters.
  • Two Sigma Investments's Talphera position peaked at $1.29M in Q4 2018.
  • 45 funds tracked by Wall St. Rank held Talphera as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.