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Talphera

38 hedge funds and large institutions have $23.8M invested in Talphera in 2025 Q4 according to their latest regulatory filings, with 10 funds opening new positions, 11 increasing their positions, 6 reducing their positions, and 6 closing their positions.

New
Increased
Maintained
Reduced
Closed

83% more repeat investments, than reductions

Existing positions increased: 11 | Existing positions reduced: 6

67% more first-time investments, than exits

New positions opened: 10 | Existing positions closed: 6

50% more capital invested

Capital invested by funds: $15.9M → $23.8M (+$7.91M)

12% more funds holding

Funds holding: 3438 (+4)

6% less call options, than puts

Call options by funds: $979K | Put options by funds: $1.04M

41.86% less ownership

Funds ownership: 86.63%44.78% (-42%)

Holders
38
Holders Change
+4
Holders Change %
+11.76%
% of All Funds
0.46%
Holding in Top 10
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
New
10
Increased
11
Reduced
6
Closed
6
Calls
$979K
Puts
$1.04M
Net Calls
-$64K
Net Calls Change
-$311K
Name Holding Trade Value Shares
Change
Change in
Stake
ACM
1
AIGH Capital Management
Maryland
$5.31M +$250K +206,957 +5%
RSCM
2
Rock Springs Capital Management
Maryland
$4.09M
RA
3
Rosalind Advisors
Ontario, Canada
$4.08M -$972K -806,484 -18%
NCM
4
Nantahala Capital Management
Connecticut
$3.98M
EAM
5
Empery Asset Management
New York
$1.52M +$1.61M +1,333,497 New
BL
6
Bleichroeder LP
New York
$1M
Vanguard Group
7
Vanguard Group
Pennsylvania
$757K +$455K +377,448 +132%
DIG
8
Dauntless Investment Group
New Hampshire
$660K +$578K +479,320 +479%
CF
9
Cantor Fitzgerald
New York
$658K +$696K +577,490 New
Geode Capital Management
10
Geode Capital Management
Massachusetts
$391K +$214K +177,294 +107%
Renaissance Technologies
11
Renaissance Technologies
New York
$293K +$250K +207,166 +413%
DP
12
Diadema Partners
New Jersey
$156K +$165K +136,923 New
BlackRock
13
BlackRock
New York
$104K
Simplex Trading
14
Simplex Trading
Illinois
$97.8K +$102K +84,572 +6,893%
Jane Street
15
Jane Street
New York
$96.8K +$102K +84,938 New
VFA
16
Values First Advisors
Tennessee
$92.6K -$20.1K -16,674 -17%
Citadel Advisors
17
Citadel Advisors
Florida
$87.1K +$92.2K +76,445 New
Mariner
18
Mariner
Kansas
$66.1K +$39.8K +33,000 +132%
Group One Trading
19
Group One Trading
Illinois
$65.2K +$32.3K +26,758 +88%
Susquehanna International Group
20
Susquehanna International Group
Pennsylvania
$64.3K +$68K +56,432 New
Northern Trust
21
Northern Trust
Illinois
$59.9K +$50.3K +41,689 +383%
PAP
22
Persistent Asset Partners
Hong Kong
$41.8K +$44.2K +36,630 New
Two Sigma Investments
23
Two Sigma Investments
New York
$28K +$29.6K +24,588 New
State Street
24
State Street
Massachusetts
$25.3K
GCP
25
GSA Capital Partners
United Kingdom
$24K +$25.3K +20,973 New

TLPH Hedge Fund Activity: Q4 2025 in Review

38 of the 8,245 institutional investors tracked by Wall St. Rank reported a position in Talphera (TLPH) for Q4 2025, worth a combined $23.8M — up 50% from $15.9M a quarter earlier.

Buyers outnumbered sellers: 10 funds opened new TLPH positions and 6 closed out — a net gain of 4 holders — while 11 added to existing stakes and 6 trimmed.

The largest buyer was Cantor Fitzgerald, opening a new position worth an estimated $696K. The largest seller was Rosalind Advisors, cutting an estimated $972K.

  • 38 institutional investors held Talphera (TLPH) as of Q4 2025, up from 34 in Q3 2025.
  • Funds reported $23.8M of Talphera stock for Q4 2025, up 50% quarter-over-quarter.
  • 10 funds opened new Talphera positions in Q4 2025 and 6 closed out, a net change of +4 holders.
  • The largest Talphera buyer in Q4 2025 was Cantor Fitzgerald, an estimated $696K added.
  • The largest Talphera seller in Q4 2025 was Rosalind Advisors, an estimated $972K sold.

Based on aggregated 13F filings for Q4 2025.