Two Sigma Investments
ORKA

Two Sigma Investments’s Oruka Therapeutics ORKA Stock Holding History

Two Sigma Investments’s Portfolio ORKA Stock Details ORKA Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$950K Sell
19,364
-9,202
-32% -$320K ﹤0.01% 3297
2025
Q4 		$866K Hold
28,566
– – ﹤0.01% 3031
2025
Q3 		$549K Sell
28,566
-3,776
-12% -$56K ﹤0.01% 2940
2025
Q2 		$363K Buy
32,342
+10,511
+48% +$110K ﹤0.01% 2721
2025
Q1 		$224K Buy
+21,831
New +$272K ﹤0.01% 2819

Other funds holding ORKA

Fidelity Investments
Fidelity Investments Boston, Massachusetts $1.9T AUM 41.92% 1-Year Est. Return
VA
VR Adviser New York $2.68B AUM 422.73% 1-Year Est. Return
FFM
Fairmount Funds Management West Conshohocken, Pennsylvania $1.38B AUM 407.79% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
Viking Global Investors
Viking Global Investors Stamford, Connecticut $35.7B AUM 21.3% 1-Year Est. Return
PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return
RI
RTW Investments New York $10B AUM 135.35% 1-Year Est. Return
DTC
Deep Track Capital Greenwich, Connecticut $6.12B AUM 144% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
APM
Avidity Partners Management Dallas, Texas $936M AUM 195% 1-Year Est. Return

Two Sigma Investments's ORKA Position: Q1 2026 in Review

Two Sigma Investments reduced its Oruka Therapeutics (ORKA) stake by 32% in Q1 2026, selling an estimated $320K and leaving 19,364 shares worth $950K. The position accounts for ﹤0.01% of the portfolio, ranked #3297.

Two Sigma Investments first reported a position in ORKA in Q1 2025 and has held it in 5 quarters since. 184 funds tracked by Wall St. Rank hold ORKA as of Q1 2026.

  • Two Sigma Investments held 19,364 shares of Oruka Therapeutics worth $950K as of Q1 2026.
  • Two Sigma Investments sold 9,202 Oruka Therapeutics shares in Q1 2026, an estimated $320K.
  • Oruka Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #3297 holding.
  • Two Sigma Investments first reported a position in Oruka Therapeutics in Q1 2025 and has held it in 5 quarters since.
  • 184 funds tracked by Wall St. Rank held Oruka Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.