Two Sigma Investments
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Two Sigma Investments’s OptimizeRx OPRX Stock Holding History

Two Sigma Investments’s Portfolio OPRX Stock Details OPRX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2022
Q1 		– Sell
-10,700
Closed -$665K – 3855
2021
Q4 		$665K Buy
10,700
+2,300
+27% +$174K ﹤0.01% 2956
2021
Q3 		$719K Buy
+8,400
New +$527K ﹤0.01% 2930

Other funds holding OPRX

WCA
Whetstone Capital Advisors Shawnee Mission, Kansas $288M AUM 44.06% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RA
Royce & Associates New York $10.1B AUM 42.88% 1-Year Est. Return
PHP
Parkman Healthcare Partners Stamford, Connecticut $970M AUM 79.46% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
KCM
Kennedy Capital Management St Louis, Missouri $4.72B AUM 36.69% 1-Year Est. Return
William Blair & Company
William Blair & Company Chicago, Illinois $34.9B AUM 18.88% 1-Year Est. Return
RHJA
Rice Hall James & Associates San Diego, California $1.8B AUM 36.16% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's OPRX Position: Q1 2026 in Review

Two Sigma Investments sold out of OptimizeRx (OPRX) in Q1 2026, closing a stake of 46,181 shares — an estimated $566K sold.

Two Sigma Investments first reported a position in OPRX in Q2 2019 and held it in 17 quarters. The position peaked at $12M in Q1 2021. 128 funds tracked by Wall St. Rank hold OPRX as of Q1 2026.

  • Two Sigma Investments reported no remaining OptimizeRx position as of Q1 2026 after selling out during the quarter.
  • Two Sigma Investments sold 46,181 OptimizeRx shares in Q1 2026, an estimated $566K.
  • Two Sigma Investments first reported a position in OptimizeRx in Q2 2019 and held it in 17 quarters.
  • Two Sigma Investments's OptimizeRx position peaked at $12M in Q1 2021.
  • 128 funds tracked by Wall St. Rank held OptimizeRx as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.