Two Sigma Investments
OPRX icon

Two Sigma Investments’s OptimizeRx OPRX Stock Holding History

Two Sigma Investments’s Portfolio OPRX Stock Details OPRX Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		– Sell
-46,181
Closed -$566K – 4827
2025
Q4 		$566K Sell
46,181
-17,523
-28% -$286K ﹤0.01% 3237
2025
Q3 		$1.31M Sell
63,704
-39,041
-38% -$619K ﹤0.01% 2411
2025
Q2 		$1.39M Buy
102,745
+53,709
+110% +$588K ﹤0.01% 2059
2025
Q1 		$425K Buy
+49,036
New +$300K ﹤0.01% 2590
2023
Q3 		– Sell
-90,462
Closed -$1.29M – 3141
2023
Q2 		$1.29M Sell
90,462
-19,517
-18% -$278K ﹤0.01% 1794
2023
Q1 		$1.61M Sell
109,979
-16,951
-13% -$284K ﹤0.01% 1547
2022
Q4 		$2.13M Sell
126,930
-104,479
-45% -$1.81M 0.01% 1298
2022
Q3 		$3.43M Buy
231,409
+206,308
+822% +$4.08M 0.01% 909
2022
Q2 		$688K Sell
25,101
-108,469
-81% -$3.21M ﹤0.01% 1698
2022
Q1 		$5.04M Buy
133,570
+4,171
+3% +$185K 0.01% 923
2021
Q4 		$8.04M Buy
129,399
+56,140
+77% +$4.25M 0.02% 914
2021
Q3 		$6.27M Sell
73,259
-97,867
-57% -$6.14M 0.01% 1063
2021
Q2 		$10.6M Sell
171,126
-75,492
-31% -$3.84M 0.02% 767
2021
Q1 		$12M Buy
246,618
+195,307
+381% +$9.42M 0.03% 630
2020
Q4 		$1.6M Buy
+51,311
New +$1.26M ﹤0.01% 1645
2020
Q3 		– Sell
-10,200
Closed -$133K – 3432
2020
Q2 		$133K Buy
+10,200
New +$111K ﹤0.01% 2747
2019
Q3 		– Sell
-23,540
Closed -$381K – 3712
2019
Q2 		$381K Buy
+23,540
New +$318K ﹤0.01% 2697

Other funds holding OPRX

WCA
Whetstone Capital Advisors Shawnee Mission, Kansas $288M AUM 44.06% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
RA
Royce & Associates New York $10.1B AUM 42.88% 1-Year Est. Return
PHP
Parkman Healthcare Partners Stamford, Connecticut $970M AUM 79.46% 1-Year Est. Return
VCM
Vanguard Capital Management Malvern, Pennsylvania $4.04T AUM
KCM
Kennedy Capital Management St Louis, Missouri $4.72B AUM 36.69% 1-Year Est. Return
William Blair & Company
William Blair & Company Chicago, Illinois $34.9B AUM 18.88% 1-Year Est. Return
RHJA
Rice Hall James & Associates San Diego, California $1.8B AUM 36.16% 1-Year Est. Return
Dimensional Fund Advisors
Dimensional Fund Advisors Austin, Texas $481B AUM 30.42% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return