Two Sigma Investments
LXEO icon

Two Sigma Investments’s Lexeo Therapeutics LXEO Stock Holding History

Two Sigma Investments’s Portfolio LXEO Stock Details LXEO Fund Activity
Bought
Maintained
Sold
Quarter Market Value Status Shares Change in
Stake 		Trade Value Portfolio Weight Portfolio Position
2026
Q1 		$1.04M Sell
181,676
-218,891
-55% -$1.55M ﹤0.01% 3243
2025
Q4 		$3.98M Buy
400,567
+315,804
+373% +$2.88M 0.01% 1913
2025
Q3 		$563K Buy
84,763
+15,521
+22% +$75.1K ﹤0.01% 2928
2025
Q2 		$278K Buy
69,242
+32,618
+89% +$107K ﹤0.01% 2816
2025
Q1 		$127K Buy
+36,624
New +$162K ﹤0.01% 2932

Other funds holding LXEO

PBA
Paradigm Biocapital Advisors New York $4.89B AUM 251.12% 1-Year Est. Return
BlackRock
BlackRock New York $5.72T AUM 30.48% 1-Year Est. Return
AAA
Affinity Asset Advisors New York $1.94B AUM 374.45% 1-Year Est. Return
RCM
RA Capital Management Boston, Massachusetts $9.44B AUM 157.3% 1-Year Est. Return
Janus Henderson Group
Janus Henderson Group London, United Kingdom $209B AUM 37.72% 1-Year Est. Return
VPC
Vestal Point Capital New York $3.58B AUM 189.12% 1-Year Est. Return
FLSM
Frazier Life Sciences Management Palo Alto, California $3.89B AUM 201.1% 1-Year Est. Return
Citadel Advisors
Citadel Advisors Miami, Florida $618B AUM 30.34% 1-Year Est. Return
O
OrbiMed New York $5.05B AUM 125.28% 1-Year Est. Return
State Street
State Street Boston, Massachusetts $2.9T AUM 29.55% 1-Year Est. Return

Two Sigma Investments's LXEO Position: Q1 2026 in Review

Two Sigma Investments reduced its Lexeo Therapeutics (LXEO) stake by 55% in Q1 2026, selling an estimated $1.55M and leaving 181,676 shares worth $1.04M. The position accounts for ﹤0.01% of the portfolio, ranked #3243.

Two Sigma Investments first reported a position in LXEO in Q1 2025 and has held it in 5 quarters since. The position peaked at $3.98M in Q4 2025. 139 funds tracked by Wall St. Rank hold LXEO as of Q1 2026.

  • Two Sigma Investments held 181,676 shares of Lexeo Therapeutics worth $1.04M as of Q1 2026.
  • Two Sigma Investments sold 218,891 Lexeo Therapeutics shares in Q1 2026, an estimated $1.55M.
  • Lexeo Therapeutics made up ﹤0.01% of Two Sigma Investments's portfolio in Q1 2026, its #3243 holding.
  • Two Sigma Investments first reported a position in Lexeo Therapeutics in Q1 2025 and has held it in 5 quarters since.
  • Two Sigma Investments's Lexeo Therapeutics position peaked at $3.98M in Q4 2025.
  • 139 funds tracked by Wall St. Rank held Lexeo Therapeutics as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.