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Lexeo Therapeutics

146 hedge funds and large institutions have $759M invested in Lexeo Therapeutics in 2025 Q4 according to their latest regulatory filings, with 47 funds opening new positions, 61 increasing their positions, 26 reducing their positions, and 9 closing their positions.

New
Increased
Maintained
Reduced
Closed

422% more first-time investments, than exits

New positions opened: 47 | Existing positions closed: 9

135% more repeat investments, than reductions

Existing positions increased: 61 | Existing positions reduced: 26

132% more capital invested

Capital invested by funds: $327M → $759M (+$432M)

34% more funds holding

Funds holding: 109146 (+37)

13.42% more ownership

Funds ownership: 91.34%104.76% (+13%)

0% more funds holding in top 10

Funds holding in top 10: 11 (0)

5% less call options, than puts

Call options by funds: $136K | Put options by funds: $143K

Holders
146
Holders Change
+37
Holders Change %
+33.94%
% of All Funds
1.78%
Holding in Top 10
1
Holding in Top 10 Change
Holding in Top 10 Change %
% of All Funds
0.01%
New
47
Increased
61
Reduced
26
Closed
9
Calls
$136K
Puts
$143K
Net Calls
-$7K
Net Calls Change
+$77K
Name Holding Trade Value Shares
Change
Change in
Stake
Janus Henderson Group
1
Janus Henderson Group
United Kingdom
$54.7M -$5.44M -595,892 -10%
RCM
2
RA Capital Management
Massachusetts
$49.6M +$45.6M +5,000,000 New
BlackRock
3
BlackRock
New York
$48.7M +$25M +2,736,471 +126%
PBA
4
Paradigm Biocapital Advisors
New York
$47.3M +$43.5M +4,763,198 New
VPC
5
Vestal Point Capital
New York
$44.4M +$11.2M +1,225,000 +38%
FLSM
6
Frazier Life Sciences Management
California
$43.9M
Vanguard Group
7
Vanguard Group
Pennsylvania
$38.7M +$15.2M +1,668,020 +75%
Citadel Advisors
8
Citadel Advisors
Florida
$37.5M +$504K +55,274 +1%
ACA
9
Avoro Capital Advisors
New York
$32.8M +$30.1M +3,300,000 New
AAA
10
Affinity Asset Advisors
New York
$31.8M -$6.12M -670,527 -17%
WP
11
Woodline Partners
California
$31.8M +$5.71M +625,598 +24%
State Street
12
State Street
Massachusetts
$31.7M +$24.1M +2,642,877 +485%
O
13
OrbiMed
New York
$21.1M +$19.4M +2,125,000 New
Point72 Asset Management
14
Point72 Asset Management
Connecticut
$18.8M -$430K -47,127 -2%
OCA
15
Octagon Capital Advisors
New York
$17.1M +$15.7M +1,725,000 New
Balyasny Asset Management
16
Balyasny Asset Management
Illinois
$16.2M -$20.8M -2,278,762 -58%
Geode Capital Management
17
Geode Capital Management
Massachusetts
$14.4M +$6.61M +724,006 +100%
ACM
18
ADAR1 Capital Management
Texas
$13.8M -$1.27M -138,792 -9%
SCM
19
Suvretta Capital Management
New York
$12.4M +$11.4M +1,250,000 New
6CM
20
683 Capital Management
New York
$11.1M +$1.8M +197,338 +21%
NCM
21
Nantahala Capital Management
Connecticut
$9.93M +$9.13M +1,000,000 New
Millennium Management
22
Millennium Management
New York
$9.02M -$12.8M -1,405,618 -61%
Blackstone Inc
23
Blackstone Inc
New York
$8.99M -$2.01M -219,963 -20%
Dimensional Fund Advisors
24
Dimensional Fund Advisors
Texas
$8.57M -$453K -49,641 -5%
Goldman Sachs
25
Goldman Sachs
New York
$7.76M +$5.84M +639,453 +449%