Two Sigma Investments’s iShares Biotechnology ETF IBB Stock Holding History

Two Sigma Investments’s Portfolio IBB Stock Details IBB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2022 Q1	–	Sell	-6,600	Closed	-$1.01M	–	3416
2021 Q4	$1.01M	Sell	6,600 -2,400	-27%	-$372K	﹤0.01%	2557
2021 Q3	$1.46M	Sell	9,000 -12,000	-57%	-$2.02M	﹤0.01%	2275
2021 Q2	$3.44M	Buy	+21,000	New	+$3.23M	0.01%	1448
2020 Q4	–	Sell	-3,000	Closed	-$406K	–	3515
2020 Q3	$406K	Sell	3,000 -11,000	-79%	-$1.49M	﹤0.01%	2386
2020 Q2	$1.91M	Buy	14,000 +3,100	+28%	+$395K	0.01%	1125
2020 Q1	$1.17M	Buy	+10,900	New	+$1.25M	0.01%	1302
2019 Q4	–	Sell	-21,000	Closed	-$2.09M	–	3792
2019 Q3	$2.09M	Buy	21,000 +12,000	+133%	+$1.26M	0.01%	1399
2019 Q2	$982K	Buy	+9,000	New	+$957K	﹤0.01%	1943
2018 Q4	–	Sell	-6,000	Closed	-$732K	–	3224
2018 Q3	$732K	Sell	6,000 -25,000	-81%	-$2.94M	﹤0.01%	2200
2018 Q2	$3.4M	Buy	31,000 +24,000	+343%	+$2.57M	0.01%	1258
2018 Q1	$747K	Buy	+7,000	New	+$776K	﹤0.01%	2208

Other funds holding IBB

Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return

Citigroup New York $235B AUM 32.99% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

BNP Paribas Financial Markets Paris, France $206B AUM 31.61% 1-Year Est. Return

JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Envestnet Asset Management Chicago, Illinois $374B AUM 17.66% 1-Year Est. Return

Raymond James Financial St Petersburg, Florida $324B AUM 22.36% 1-Year Est. Return

Commerce Bank Kansas City, Missouri $20.7B AUM 23.76% 1-Year Est. Return

Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return

Two Sigma Investments's IBB Position: Q1 2026 in Review

Two Sigma Investments reduced its iShares Biotechnology ETF (IBB) stake by 62% in Q1 2026, selling an estimated $157M and leaving 557,807 shares worth $94.2M. The position accounts for 0.08% of the portfolio, ranked #292.

Two Sigma Investments first reported a position in IBB in Q1 2014 and has held it in 36 quarters since. The position peaked at $249M in Q4 2025. 919 funds tracked by Wall St. Rank hold IBB as of Q1 2026.

Two Sigma Investments held 557,807 shares of iShares Biotechnology ETF worth $94.2M as of Q1 2026.
Two Sigma Investments sold 917,200 iShares Biotechnology ETF shares in Q1 2026, an estimated $157M.
iShares Biotechnology ETF made up 0.08% of Two Sigma Investments's portfolio in Q1 2026, its #292 holding.
Two Sigma Investments first reported a position in iShares Biotechnology ETF in Q1 2014 and has held it in 36 quarters since.
Two Sigma Investments's iShares Biotechnology ETF position peaked at $249M in Q4 2025.
919 funds tracked by Wall St. Rank held iShares Biotechnology ETF as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.