Two Sigma Investments’s iShares Biotechnology ETF IBB Stock Holding History

Two Sigma Investments’s Portfolio IBB Stock Details IBB Fund Activity

Bought

Maintained

Sold

Quarter	Market Value	Status	Shares	Change in Stake	Trade Value	Portfolio Weight	Portfolio Position
2022 Q1	–	Sell	-3,900	Closed	-$595K	–	3415
2021 Q4	$595K	Sell	3,900 -1,100	-22%	-$170K	﹤0.01%	3076
2021 Q3	$808K	Sell	5,000 -12,000	-71%	-$2.02M	﹤0.01%	2811
2021 Q2	$2.78M	Buy	17,000 +15,000	+750%	+$2.31M	0.01%	1603
2021 Q1	$301K	Buy	+2,000	New	+$318K	﹤0.01%	3319
2020 Q4	–	Sell	-3,000	Closed	-$406K	–	3514
2020 Q3	$406K	Sell	3,000 -1,000	-25%	-$136K	﹤0.01%	2385
2020 Q2	$547K	Sell	4,000 -2,000	-33%	-$255K	﹤0.01%	1941
2020 Q1	$646K	Buy	+6,000	New	+$691K	0.01%	1752
2019 Q4	–	Sell	-20,000	Closed	-$1.99M	–	3791
2019 Q3	$1.99M	Buy	20,000 +12,000	+150%	+$1.26M	0.01%	1447
2019 Q2	$873K	Buy	+8,000	New	+$851K	﹤0.01%	2049
2018 Q4	–	Sell	-6,000	Closed	-$732K	–	3223
2018 Q3	$732K	Sell	6,000 -23,000	-79%	-$2.71M	﹤0.01%	2199
2018 Q2	$3.19M	Buy	29,000 +24,000	+480%	+$2.57M	0.01%	1308
2018 Q1	$534K	Buy	+5,000	New	+$554K	﹤0.01%	2436

Other funds holding IBB

Bank of America Charlotte, North Carolina $1.37T AUM 24.88% 1-Year Est. Return

Citigroup New York $235B AUM 32.99% 1-Year Est. Return

Morgan Stanley New York $1.66T AUM 25.57% 1-Year Est. Return

BNP Paribas Financial Markets Paris, France $206B AUM 31.61% 1-Year Est. Return

JP Morgan Chase New York $1.56T AUM 27.86% 1-Year Est. Return

Goldman Sachs New York $871B AUM 31.28% 1-Year Est. Return

Envestnet Asset Management Chicago, Illinois $374B AUM 17.66% 1-Year Est. Return

Raymond James Financial St Petersburg, Florida $324B AUM 22.36% 1-Year Est. Return

Commerce Bank Kansas City, Missouri $20.7B AUM 23.76% 1-Year Est. Return

Wells Fargo San Francisco, California $530B AUM 22.01% 1-Year Est. Return

Two Sigma Investments's IBB Position: Q1 2026 in Review

Two Sigma Investments reduced its iShares Biotechnology ETF (IBB) stake by 62% in Q1 2026, selling an estimated $157M and leaving 557,807 shares worth $94.2M. The position accounts for 0.08% of the portfolio, ranked #292.

Two Sigma Investments first reported a position in IBB in Q1 2014 and has held it in 36 quarters since. The position peaked at $249M in Q4 2025. 919 funds tracked by Wall St. Rank hold IBB as of Q1 2026.

Two Sigma Investments held 557,807 shares of iShares Biotechnology ETF worth $94.2M as of Q1 2026.
Two Sigma Investments sold 917,200 iShares Biotechnology ETF shares in Q1 2026, an estimated $157M.
iShares Biotechnology ETF made up 0.08% of Two Sigma Investments's portfolio in Q1 2026, its #292 holding.
Two Sigma Investments first reported a position in iShares Biotechnology ETF in Q1 2014 and has held it in 36 quarters since.
Two Sigma Investments's iShares Biotechnology ETF position peaked at $249M in Q4 2025.
919 funds tracked by Wall St. Rank held iShares Biotechnology ETF as of Q1 2026.

Based on Two Sigma Investments's 13F filing for Q1 2026, filed 15 May 2026.