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PFM Health Sciences Portfolio holdings

AUM $1.1B
1-Year Est. Return 57.92%
This Fund
S&P 500
This Quarter Est. Return
+12.45%
1 Year Est. Return
+57.92%
3 Year Est. Return
+183.93%
5 Year Est. Return
+283%
10 Year Est. Return
+2,507.28%
AUM
$1.3B
AUM Growth
+$126M
Cap. Flow
+$12.8M
Cap. Flow %
0.98%
Top 10 Hldgs %
49.24%
Holding
85
New
28
Increased
16
Reduced
23
Closed
13

Top Buys

Rank Stock Value
1
UHS icon
Universal Health Services
UHS
+$20.9M
2
ADMA icon
ADMA Biologics
ADMA
+$20.2M
3
UTHR icon
United Therapeutics
UTHR
+$19.9M
4
MRK icon
Merck
MRK
+$19.5M
5
ELV icon
Elevance Health
ELV
+$18.9M

Top Sells

Rank Stock Value
1
LLY icon
Eli Lilly
LLY
+$31.9M
2
DHR icon
Danaher
DHR
+$31.9M
3
HUM icon
Humana
HUM
+$27.8M
4
MOH icon
Molina Healthcare
MOH
+$25.5M
5
ALNY icon
Alnylam Pharmaceuticals
ALNY
+$23.6M

Sector Composition

Rank Sector Weight
1 Healthcare 87.87%
Name Market Value Portfolio Weight Shares or Principal Change
in Stake 		Capital Flow
WST icon
51
West Pharmaceutical
WST
$24.7B
$4.82M 0.37%
+18,365
New +$4.46M
AZN icon
52
AstraZeneca
AZN
$250B
$4.74M 0.36%
+30,898
New +$4.68M
ARGX icon
53
argenx
ARGX
$54.3B
$4.72M 0.36%
6,403
-834
-12% -$550K
RZLT icon
54
Rezolute
RZLT
$451M
$4.26M 0.33%
452,733
+18,599
+4% +$124K
SNDX icon
55
Syndax Pharmaceuticals
SNDX
$1.78B
$3.95M 0.3%
+256,488
New +$3.36M
MBX
56
MBX Biosciences
MBX
$3.21B
$3.88M 0.3%
+221,505
New +$2.96M
AMRX icon
57
Amneal Pharmaceuticals
AMRX
$5.89B
$3.56M 0.27%
+355,818
New +$3.19M
GPCR icon
58
Structure Therapeutics
GPCR
$3.59B
$3.22M 0.25%
115,073
+58,479
+103% +$1.16M
PRAX icon
59
Praxis Precision Medicines
PRAX
$8.9B
$3.21M 0.25%
60,578
-24,135
-28% -$1.17M
ELVN icon
60
Enliven Therapeutics
ELVN
$4.26B
$3.2M 0.25%
+156,463
New +$3.15M
CRBU icon
61
Caribou Biosciences
CRBU
$160M
$3.17M 0.24%
1,358,831
– –
BSX icon
62
Boston Scientific
BSX
$69.2B
$2.8M 0.22%
+28,648
New +$2.97M
QURE icon
63
uniQure
QURE
$3.07B
$2.71M 0.21%
46,353
-127,978
-73% -$2.32M
DNTH icon
64
Dianthus Therapeutics
DNTH
$6.29B
$2.67M 0.21%
+67,840
New +$1.73M
IRON icon
65
Disc Medicine
IRON
$3.03B
$2.15M 0.17%
32,539
+1,740
+6% +$104K
LQDA icon
66
PUT
Liquidia Corp
LQDA
$7.93B
$1.74M 0.13%
+76,300
New +$1.66M
HIMS icon
67
Hims & Hers Health
HIMS
$7.33B
$1.3M 0.1%
+22,915
New +$1.17M
TMO icon
68
Thermo Fisher Scientific
TMO
$214B
$1.12M 0.09%
+2,314
New +$1.08M
HUM icon
69
Humana
HUM
$43.7B
$949K 0.07%
3,648
-105,863
-97% -$27.8M
DFTX
70
Definium Therapeutics
DFTX
$5.62B
$886K 0.07%
+75,138
New +$701K
HOWL icon
71
Werewolf Therapeutics
HOWL
$19.5M
$790K 0.06%
401,110
– –
ABBV icon
72
AbbVie
ABBV
$435B
– –
-40,782
Closed -$7.57M
ALNY icon
73
Alnylam Pharmaceuticals
ALNY
$30.6B
– –
-72,220
Closed -$23.6M
BMRN icon
74
BioMarin Pharmaceuticals
BMRN
$11.7B
– –
-178,319
Closed -$9.8M
BPMC
75
DELISTED
Blueprint Medicines
BPMC
– –
-48,444
Closed -$6.21M
1 2
3
4

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PFM Health Sciences's Q3 2025 Portfolio in Review

As of Q3 2025, PFM Health Sciences held 85 positions worth $1.3B, up 11% from $1.17B the previous quarter. Its ten largest holdings account for 49% of the portfolio.

PFM Health Sciences's Q3 2025 filing shows 28 new, 16 increased, 23 reduced and 13 closed positions. Its largest new stake was Universal Health Services: 116,260 shares worth $23.8M. The largest sale was Eli Lilly, an estimated $31.9M.

By sector, the portfolio is most concentrated in Healthcare at 88% of assets, down from 95% a quarter earlier.

  • PFM Health Sciences's largest Q3 2025 buy was Universal Health Services: 116,260 shares worth $23.8M.
  • PFM Health Sciences added most to United Therapeutics in Q3 2025, an estimated $19.9M increase.
  • PFM Health Sciences's biggest Q3 2025 reduction was Eli Lilly, cutting an estimated $31.9M.
  • PFM Health Sciences fully exited Danaher in Q3 2025, selling an estimated $31.9M.
  • PFM Health Sciences's ten largest holdings make up 49% of its $1.3B portfolio in Q3 2025.
  • PFM Health Sciences opened 28 new positions and closed 13 in Q3 2025.
  • PFM Health Sciences's portfolio value rose 11% quarter-over-quarter to $1.3B.

Based on PFM Health Sciences's 13F filing for Q3 2025, filed 14 Nov 2025.