PBA

Paradigm Biocapital Advisors Portfolio holdings

AUM $2.17B

AUM

$2.17B

AUM Growth

-$702M (-24%)

Cap. Flow

-$67.2M

Cap. Flow % of AUM

-3.09%

Top 10 Holdings %Top 10 Hldgs %

76.41%

Holding

33

New

5

Increased

11

Reduced

10

Closed

6

Top Buys

1	Merus MRUS	$70.7M
2	Cytokinetics CYTK	$34.5M
3	Insmed INSM	$34.4M
4	MTSR Metsera, Inc. Common Stock MTSR	$32.4M
5	Cogent Biosciences COGT	$24.2M

Top Sells

1	argenx ARGX	$250M
2	MoonLake Immunotherapeutics MLTX	$44.7M
3	Immatics IMTX	$15.8M
4	Disc Medicine IRON	$14.2M
5	Revolution Medicines RVMD	$13.3M

Sector Composition

1

Healthcare

100%

#	Name	Market Value	Portfolio Weight	Shares or Principal	Shares Change %	Capital Flow
26	26 Ocular Therapeutix OCUL $1.16B	$9.63M	0.44%	1,314,018	New	+$9.63M
27	27 Immatics IMTX $621M	$8.6M	0.39%	1,907,108 -3,507,301	-65%	-$15.8M
28	28 Agios Pharmaceuticals AGIO $1.73B	$0	0%	0 -276,439	Closed	–
29	29 Pliant Therapeutics PLRX $79.2M	$0	0%	0 -3,197,050	Closed	–
30	30 Scholar Rock SRRK $2.85B	$0	0%	0 -400,000	Closed	–
31	31 Vera Therapeutics VERA $1.25B	$0	0%	0 -1,437,339	Closed	–
32	TECX 32 Tectonic Therapeutic, Inc. Common Stock TECX $404M	$0	0%	0 -485,105	Closed	–
33	ORKA 33 Oruka Therapeutics, Inc. Common Stock ORKA $410M	$0	0%	0 -819,660	Closed	–